SynthesisEvidence-based dentistry2025
The association between maternal smoking during pregnancy and dental development in offspring: a systematic review.
Synthesis in Evidence-based dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
aimTo investigate the effect of maternal smoking during pregnancy (MSDP) on the development of dental conditions in human offspring, as presented in current literature.
methodsObservational studies from six databases (MEDLINE, Embase, CINAHL, Scopus, Web of Science and Maternity and Infant Care (MIC)) were systematically searched in July 2024. Articles were screened based on their investigation of the effect of MSDP on the development of dental conditions in offspring. Methodological quality was assessed using the Newcastle Ottawa Scale (NOS), while the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.
resultsA total of 17 articles were included in this review, focusing on the primary dental developmental outcomes: molar incisor hypomineralisation (MIH), enamel defects (other than MIH), missing teeth, dental eruption, and short root anomaly. Due to high levels of heterogeneity among the studies, meta-analysis was not performed. The majority of studies demonstrated good methodological quality (n = 10), with three assessed as fair and four as poor. The quality of evidence was categorised, with three outcomes receiving a low quality of evidence classification, and tooth eruption and short root anomaly being classed as very low quality. Statistically significant associations between MSDP and each dental outcome had varied results across studies. Most studies concluded an association between MSDP and conditions such as enamel defects (other than MIH), missing teeth, and short root anomaly. Some studies found associations with MIH, while the majority found no link between MSDP and tooth eruption in offspring.
conclusionThis review suggests a potential association between MSDP and dental development conditions in offspring. However, due to the low quality of evidence and inconsistencies in findings across observational studies, a definitive association cannot be drawn. Further, novel and high-quality research is needed to understand the impact MSDP on dental development in offspring.
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