ReviewNature2025
The history and future of resting-state functional magnetic resonance imaging.
Review in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review on dysconnectivity in face and emotion processing networks in schizophrenia.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis.Psychological medicine · 2025Pooled it
- Associations between chronic placental inflammation, fetal brain development and later autism traits.Brain, behavior, & immunity - health · 2026Article
- Age-related degradation of cerebellar functional network topology.GeroScience · 2026Article
- Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.Molecular psychiatry · 2026Article
- Financial Decision Making in Older Adults Is Associated With Frontoparietal-Salience Between-Network Connectivity.Journal of neuroscience, psychology, and economics · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome.Brain, behavior, & immunity - health · 2026Article
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Article
- Topological Alterations of Functional Brain Networks in Post-Stroke Cognitive Impairment: a Graph-Theoretical Study.Clinical neuroradiology · 2026Article
- A Low-Cost Modular Multi-Region Electrode for Distributed Network Recording and Brain State Decoding.Brain sciences · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Monosynaptic connections link functionally similar regions in human cortex.bioRxiv : the preprint server for biology · 2026Article
- Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts.Biological psychiatry · 2026Review
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- Linking human brain functional connectivity to underlying neurotransmission.bioRxiv : the preprint server for biology · 2026Article
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Mapping Functional Brain Organization Using Artificial Intelligence.Chemical & biomedical imaging · 2026Review
- Towards a general-purpose foundation model for functional MRI analysis.Nature biomedical engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Since the discovery of resting-state functional connectivity in the human brain, this neuroimaging approach has revolutionized the study of neural architecture. Once considered noise, the functional significance of spontaneous low-frequency fluctuations across large-scale brain networks has now been investigated in more than 25,000 publications. In this Review, we provide a historical overview and thoughts regarding potential future directions for resting-state functional MRI (rsfMRI) research, highlighting the most informative analytic approaches that have been developed to reveal the brain's intrinsic spatiotemporal organization. We review the collaborative efforts that have led to the widespread use of rsfMRI in neuroscience, with an emphasis on methodological innovations that have been made possible by contributions from electrical and biomedical engineering, physics, mathematics and computer science. We focus on key theoretical and methodological advances that will be necessary for further progress in the field, highlighting the need for further integration with new developments in whole-brain computational modelling, more sophisticated approaches to brain-behaviour mapping, greater mechanistic insights from concurrent measurement of neurophysiology, and greater appreciation of the problem of generalization failure in machine learning applications. We propose that rsfMRI has the potential for even greater clinical relevance when it is fully integrated with population neuroscience and global health initiatives in the service of precision psychiatry.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.