Evidence map›Paper›PMID 40437175›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Association between general anesthesia combined with peripheral nerve blocks versus neuraxial anesthesia without nerve blocks for high-risk isolated distal deep venous thrombosis in patients undergoing knee arthroplasty: a historical cohort study.

Nanbo Luo, Li Luo, Lei Yang, Zhi Li, Qingmin Yu, Wenling Jian, Wei Sun, Pac-Soo Chen, Qian Chen, Daqing Ma and 5 more

Erratum issuedAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Nanbo Luo *Department of Anesthesiology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Li Luo *Department of Anesthesiology, Shenzhen Futian District Maternity and Child Healthcare Hospital, Shenzhen, China.
Lei YangDepartment of Orthopedics, Institute of Translational Medicine, Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Zhi LiDepartment of Anesthesiology, Second People's Hospital of Futian District, Shenzhen, China.
Qingmin YuDepartment of Anesthesiology, Institute of Translational Medicine, Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Wenling JianDepartment of Anesthesiology, Institute of Translational Medicine, Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Wei SunDepartment of Orthopedics, Institute of Translational Medicine, Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Pac-Soo ChenDepartment of Anesthesiology, Wycombe General Hospital, Buckinghamshire, UK.
Qian ChenDivision of Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
Daqing MaDivision of Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
Qingsheng XueDepartment of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yan LuoDepartment of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Buwei YuDepartment of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Hao Wang *Department of Anesthesiology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Zhiheng Liu *Department of Anesthesiology, Institute of Translational Medicine, Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University, Shenzhen, China. zhiheng_liu_tongji@163.com.

Funding

Sanming Project of Medicine in Shenzhen SZSM202211007Shenzhen Second People' s Hospital Clinical Research Fund of Guangdong Province High-Level Hospital Construction Project 20193357001Shenzhen Second People' s Hospital Clinical Research Fund of Guangdong Province High-Level Hospital Construction Project 20223357001Shenzhen Second People' s Hospital Clinical Research Fund of Guangdong Province High-Level Hospital Construction Project 20223357006
6 · The paper itself

Abstract

purposeGeneral anesthesia combined with peripheral nerve blocks has become a common anesthesia regimen for knee replacement surgery. Its association with high-risk isolated distal deep venous thrombosis (IDDVT) remains uncertain.

methodsIn this cohort study, we obtained consecutive data from the electronic inpatient records of Shenzhen Second People's Hospital, including adults who underwent knee arthroplasty from 1 September 2019 to 31 August 2021. The primary outcome was the incidence of high-risk IDDVT. We compared the outcomes in patients who received general anesthesia combined with nerve blocks with those in patients who received neuraxial anesthesia without nerve blocks, using a multivariable regression model with inverse probability weighting according to the propensity score.

resultsOf the 848 patients who underwent knee arthroplasty, 330 were excluded because they lacked thrombus testing or had received other types of anesthesia. Of the remaining 518 patients, 267/518 (52%) received general anesthesia combined with nerve blocks and 251/518 (48%) received neuraxial anesthesia with no nerve blocks. A total of 99 patients developed high-risk IDDVT. In the primary multivariable analysis with inverse probability weighting according to the propensity score, general anesthesia combined with nerve blocks was associated with a significantly reduced high-risk IDDVT compared with neuraxial anesthesia without nerve blocks (odds ratio, 0.50; 95% confidence interval, 0.31 to 0.81; P = 0.005). The results of multiple sensitivity analyses were similar between the two cohorts. E-value analysis suggested robustness to unmeasured confounding.

conclusionsCompared with neuraxial anesthesia without peripheral nerve blocks, general anesthesia combined with peripheral nerve blocks in patients undergoing knee arthroplasty was associated with a reduced incidence of high-risk IDDVT in our retrospective study. A large multicentre prospective clinical trial is needed to validate our findings. STUDY REGISTRATION: ChiCTR.org.cn ( ChiCTR2200057006 ), first submitted 25 February 2022.

Indexed as

Anesthesia, GeneralArthroplasty, Replacement, KneeNerve BlockPostoperative ComplicationsVenous ThrombosisAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedPropensity ScoreRetrospective Studiesdeep venous thrombosisgeneral anesthesiaisolated distal deep venous thrombosisknee arthroplastyneuraxial anesthesiaperipheral nerve block

Identifiers

PMID40437175
PMCPMC12228590

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.