Evidence map›Paper›PMID 40437222›Full record

ArticleCommunications biology2025

Methylation risk score of C-reactive protein associates sleep health with related health outcomes.

Ziqing Wang, Danielle A Wallace, Brian W Spitzer, Tianyi Huang, Kent D Taylor, Jerome I Rotter, Stephen S Rich, Peter Y Liu, Martha L Daviglus, Lifang Hou and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ziqing WangCardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA. zwang14@bidmc.harvard.edu.ORCID http://orcid.org/0009-0000-4702-4681
Danielle A WallaceCardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Brian W SpitzerCardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Tianyi HuangLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Stephen S RichDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Peter Y LiuDivision of Genetics, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0003-2439-0915
Martha L DaviglusDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Alberto R RamosDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Sonya KaurDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
J Peter DurdaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Center, University of California, San Diego, La Jolla, CA, USA.
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Susan RedlineDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6585-1610
Carmen R IsasiDepartment of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-2700-9593
Tamar SoferCardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA. tsofer@bidmc.harvard.edu.ORCID http://orcid.org/0000-0001-8520-8860

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2004 to 2005
$111.5M
UCLA Clinical and Translational Science InstituteUL1TR001881 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$9.9M
Multi-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · CEDARS-SINAI MEDICAL CENTER · 2003 to 2005
$5.8M
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$5.6M
Pilot & Feasibility ProgramP30DK063491 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2003 to 2025
$5.4M
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populationsR01AG080598 · BETH ISRAEL DEACONESS MEDICAL CENTER · 2025 to 2025
$879k
MESA Family StudyR01HL071250 · NORTHWESTERN UNIVERSITY · 2003 to 2005
$852k
MESA Family StudyR01HL071258 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2003 to 2005
$780k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · 1999 to 2001
$758k
MESA Family StudyR01HL071259 · JOHNS HOPKINS UNIVERSITY · 2003 to 2005
$757k
MESA Family StudyR01HL071051 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2003 to 2005
$753k
MESA Family StudyR01HL071251 · UNIVERSITY OF MINNESOTA TWIN CITIES · 2003 to 2005
$723k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268201300003CNHGRI NIH HHS U54 HG003067NHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL161012NHLBI NIH HHS U01 HL120393NIA NIH HHS R01 AG048642NIA NIH HHS R01 AG075758NIA NIH HHS R01 AG080598NIA NIH HHS R56 AG048642NIA NIH HHS RF1 AG061022NIDDK NIH HHS P30 DK063491U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL161012
6 · The paper itself

Abstract

C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos. Via survey-weighted linear regression, we estimate associations between blood-, PRS-, and MRS-CRP, with multiple sleep and health outcomes (n = 2217). MRS-CRP and PRS-CRPs are associated with increasing blood-CRP level by 43% and 23% per standard deviation. MRS-CRP is associated with obstructive sleep apnea (OSA) traits, long sleep duration, diabetes and hypertension, while PRS-CRPs were not. Blood-CRP level is associated with sleep duration and diabetes. Adjusting for MRS-CRP weakens OSA-diabetes/hypertension associations. Consequently, MRS-CRP is a stronger marker than blood-CRP and PRS-CRP to systemic inflammation associated with poor sleep and related comorbidities.

Indexed as

C-Reactive ProteinDNA MethylationSleepAdultAgedBiomarkersFemaleHumansInflammationMaleMiddle AgedRisk FactorsSleep Apnea, ObstructiveBiomarkersC-Reactive Protein

Identifiers

PMID40437222
PMCPMC12119824

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.