Evidence map›Paper›PMID 40437306›Full record

ArticleNature aging2025

Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits.

Xiao-Qian Hu, Kenneth Lap-Kei Wu, Kang-Lin Rong, Ya Ke, Wing-Ho Yung, Daisy Kwok-Yan Shum, Ying-Shing Chan

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xiao-Qian HuDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-6142-2085
Kenneth Lap-Kei WuSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Kang-Lin RongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Ya KeSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wing-Ho YungDepartment of Neuroscience, City University of Hong Kong, Hong Kong SAR, China.
Daisy Kwok-Yan ShumSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. shumdkhk@hku.hk.ORCID http://orcid.org/0000-0002-0518-0106
Ying-Shing ChanSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. yschan@hku.hk.ORCID http://orcid.org/0000-0002-6228-1595

Funding

China Postdoctoral Science Foundation 2024M753760Research Grants Council, University Grants Committee (RGC, UGC) CRF C4012-22GResearch Grants Council, University Grants Committee (RGC, UGC) GRF 12113717Research Grants Council, University Grants Committee (RGC, UGC) GRF 14115821Research Grants Council, University Grants Committee (RGC, UGC) GRF 17125115Research Grants Council, University Grants Committee (RGC, UGC) GRF 17131816
6 · The paper itself

Abstract

Navigational decline is a metric distinct from aging-related cognitive degradation, yet the affected circuits and synaptic changes remain elusive. This study identified a long-range excitatory projection from parvalbumin (PV) neurons in the brainstem medial vestibular nucleus (MVN) of mice that monosynaptically innervates the midbrain dorsal tegmental nucleus (DTN). This PV

Indexed as

AgingSpatial NavigationVestibular NucleiAnimalsMaleMiceMice, Inbred C57BLNeural PathwaysNeuronal PlasticityNeuronsParvalbuminsParvalbumins

Identifiers

PMID40437306

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.