Evidence map›Paper›PMID 40437438›Full record

ArticleBMC oral health2025

Postoperative pain and influencing factors after prophylactic extraction of impacted mandibular third molars: a multicenter prospective cohort study.

Zhiwei Cao, Chengzhi Zhao, Renyi Wang, Qianxing Du, Kun Zhang, Jihong Zhao, Yang Xue, Bing Han, Jiuyan Jiang, Liwei Hu and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhiwei CaoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Chengzhi ZhaoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Renyi WangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Qianxing DuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Kun ZhangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Jihong ZhaoDepartment of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, 430072, China.
Yang XueState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Bing HanDepartment of Oral and Maxillofacial Surgery, School of Stomatology, Jilin University, Changchun, 130021, China.
Jiuyan JiangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Liwei HuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xuejuan LiaoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Jian PanState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. jianpancn@scu.edu.cn.

Funding

Research and Develop Program, West China Hospital of Stomatology Sichuan University RD-03-202405the Health Commission of Sichuan Province ZH2024-901the Sichuan Science and Technology Program 2023ZYD0110
6 · The paper itself

Abstract

objectiveThis study aims to investigate factors influencing postoperative pain after prophylactic third molar extraction to provide evidence-based recommendations for clinical practice.

methodsThis study enrolled 804 patients undergoing prophylactic third molar extraction. Factors potentially influencing postoperative pain were meticulously documented, including patient demographics information, tooth impaction information, surgical procedure details information, and postoperative medication regimens information. Postoperative pain was assessed using the Visual Analog Scale (VAS) at 1, 3, 7, and 30 days, while postoperative infection was documented at the same intervals. Multiple linear regression and logistic regression analyses were performed to identify potential determinants of postoperative pain.

resultsPostoperative pain generally decreased over time (1d, 3d, 7d, 30d). A lower BMI and male gender were associated with lower early postoperative VAS scores (1d, 3d), while increased age and the use of filling materials were linked to higher early and intermediate postoperative VAS scores (1d, 3d, 7d). The application of glucocorticoids was associated with increased intermediate and late postoperative VAS scores (7d, 30d). The use of postoperative antibiotics did not affect the incidence of postoperative infections.

conclusionResults indicated that protective factors for postoperative pain following prophylactic third molar extraction include male, having a lower BMI, and the use of a trapezoidal flap. Risk factors include increasing age, longer surgery duration, the use of filling materials, and the use of glucocorticoids.

Indexed as

Molar, ThirdPostoperative PainTooth ExtractionTooth, ImpactedAdolescentAdultAge FactorsBody Mass IndexFemaleGlucocorticoidsHumansMaleMandibleMiddle AgedPain MeasurementProspective StudiesGlucocorticoidsImpacted third molarInfectionPainPostoperative medicationProphylactic extraction

Identifiers

PMID40437438
PMCPMC12121015

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.