ArticleBMC medicine2025
Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Muscle Mass, Adiposity, and Bone Health in Surgical Care Setting: A Cross-Sectional Study.Journal of bone metabolism · 2026Article
- A nomogram integrating machine learning with clinical predictors for osteosarcopenia risk prediction in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Construction and validation of a multi-dimensional health indicator-driven osteoporosis risk prediction model: a large-sample cross-sectional study based on two centers.BMC musculoskeletal disorders · 2025Article
- The risk factors for chemotherapy myelosuppression in breast cancer: a systematic review and meta-analysis.Frontiers in genetics · 2025Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundWhile the protective role of body mass index (BMI) in bone mass has been well-documented, the divergent associations between BMI and estimated bone mineral density (eBMD), attributed to its highly heterogeneous nature, remain insufficiently understood.
methodsLeveraging the hitherto largest genome-wide summary statistics, we conducted a two-sample Mendelian randomization (MR) to re-evaluate the effect of genetically predicted BMI on eBMD. Then, MR-Clust was applied to examine the potential presence of distinct causal pathways underlying the BMI-eBMD link. Utilizing tissue-partitioned MR, we estimated the distinct effects of separated tissue-specific subcomponents of BMI on eBMD, further supplemented by multivariable MR of body composition phenotypes on eBMD.
resultsWe reconfirmed the significant positive association between genetically predicted BMI and eBMD (β
conclusionsOur results shed preliminary insights into the intricate relationship between obesity and bone mass, highlighting divergent causal pathways underlying the association between BMI and eBMD. Our findings emphasize the potential importance of precision obesity management over merely a general indicator as BMI in future public health strategies for osteoporosis prevention.
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Registered trials
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