Trial reportJournal of neuroengineering and rehabilitation2025
Effect of electroencephalography-based motor imagery neurofeedback on mu suppression during motor attempt in patients with stroke.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Evaluation of Cognitive Function in Stroke Patients With Lesions in Different Brain Regions Using P300 Event-Related Potentials Combined With Video EEG.Revista de neurologia · 2025Article
- Challenging the electrophysiological interpretation of mirror visual feedback in stroke.Clinical neurophysiology practice · 2025Article
- Mirror therapy combined with defecation motor imagery and repetitive transcranial magnetic stimulation improves post-stroke constipation: a retrospective study with EEG biomarker analysis.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe primary aim of this study was to explore the neurophysiological effects of motor imagery neurofeedback using electroencephalography (EEG), specifically focusing on mu suppression during serial motor attempts, and to assess its potential benefits in patients with subacute stroke.
methodsA total of 15 patients with hemiplegia following subacute ischemic stroke were prospectively enrolled in this randomized cross-over study. This study comprised two experiments: neurofeedback and sham. Each experiment included four blocks: three blocks of resting, grasp, resting, and an interventional task, followed by one block of resting and grasp. During the resting sessions, participants fixated on a white cross on a black background for 2 min without moving their upper extremities. In the grasp sessions, participants were instructed to grasp and release their paretic hand at a frequency of about 1 Hz for 3 min while maintaining fixation on the white cross. During the interventional task, the neurofeedback presented a punching image using the affected upper limb, corresponding to the mu suppression induced by imagined movement for 3 min. In contrast, the sham presented an image based on mu suppression data from randomly selected participants. EEG data were recorded throughout the experiment, and data from electrodes C3/C4 and P3/P4 were analyzed to compare the degree of mu suppression between the neurofeedback and sham experiments.
resultsSignificant mu suppression was observed in the bilateral motor and parietal cortices during the neurofeedback experiment compared with the sham across serial sessions (p < 0.001). Following neurofeedback, real grasping sessions showed progressive strengthening of mu suppression in the ipsilesional motor cortex and bilateral parietal cortices compared to sessions following sham (p < 0.05). This effect was not observed in the contralesional motor cortex.
conclusionsMotor imagery neurofeedback significantly enhances mu suppression in the ipsilesional motor and bilateral parietal cortices during motor attempts in patients with subacute stroke. These findings suggest that motor imagery neurofeedback could serve as a promising adjunctive therapy to enhance motor-related cortical activity and support motor rehabilitation in patients with stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.