Evidence mapPaperPMID 40437880Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference.

Bess Frost, James B Rowe, Rufus O Akinyemi, Jose F Abisambra, Nicholas J Ashton, Matthias Brendel, Luc Buée, David Butler, Maria C Carrillo, Peter Chung and 33 more

Abstract readConference Proceedings
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Bess FrostCenter for Alzheimer's Disease Research, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
James B RoweDepartment of Clinical Neurosciences, MRC Cognition and Brain Sciences Unit, and Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Rufus O AkinyemiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Jose F AbisambraMcKnight Brain Institute, Brain Injury, Rehabilitation, and Neuroresilience Center, Center for Translational Research in Neurodegenerative Disease, Fixel Institute, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Matthias BrendelDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Luc BuéeInserm, CHU-Lille, Lille Neuroscience & Cognition, University of Lille, Lille, France.
David ButlerNeural Stem Cell Institute, Rensselaer, New York, USA.
Maria C CarrilloMedical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.
Peter ChungDepartment of Physics and Astronomy, Department of Chemistry, and Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
Claire D ClellandWeill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Sarah L DeVosCure.Bio, Boston, Massachusetts, USA.
Kristophe DiazCurePSP, Inc, New York, New York, USA.
Rebecca M EdelmayerMedical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.
Fanny M ElahiDepartments of Neurology, Neuroscience, Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ratnavalli EllajosyulaCognitive Neurology Clinic, Manipal Hospital, and Annasawmy Mudaliar Hospital, Bengaluru, Karnataka, India.
Colin EwenUCB Pharma, Slough, UK.
Igor Camargo FontanaMedical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.
Marie-Christine GalasInserm, CHU Lille, CNRS, LilNCog-Lille Neuroscience and Cognition, University of Lille, Lille, France.
Oskar HanssonLund University, Lund, Sweden.
Günter HöglingerGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Kanta HorieThe Tracy Family SILQ Center & Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.
Agustín IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez (UAI), Peñalolén, Santiago, Chile.
Linde JacobsCure MAPT FTD, Denver, Colorado, USA.
Mahmoud B MainaSussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, UK.
Maura MalpettiDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Eric McDadeDepartment of Neurology, Washington University, St. Louis, Missouri, USA.
Will McEwanUK Dementia Research Institute, University of Cambridge, Cambridge, UK.
Laia Montoliu-GayaDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Catherine J MummeryDementia Research Centre, Institute of Neurology, University College London, London, UK.
Miranda E OrrDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jonathan D RohrerDementia Research Centre, Institute of Neurology, University College London, London, UK.
Amy RommelRainwater Charitable Foundation, Fort Worth, Texas, USA.
Carlos SastreGlobal Medical Affairs, Ferrer, Barcelona, Spain.
Tara L Spires-JonesCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Boon Lead TeeMemory & Aging Center, University of California San Francisco, San Francisco, California, USA.
Tim J VineyDepartment of Pharmacology, University of Oxford, Oxford, UK.
Jamie M WalkerDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Susanne WegmannGerman Center for Neurodegenerative Diseases, Berlin, Germany.
Kristin WildsmithEisai Inc., Nutley, New Jersey, USA.
Ravi YadavDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Simin MahinradMedical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.ORCID 0000-0002-5927-7130
Claire SextonMedical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.ORCID 0000-0002-3846-2986

Funding

Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2022 to 2025
$25.6M
Neuroimaging CoreU19AG076581 · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2025 to 2025
$5.8M
The Origins of Alzheimer Disease in African AmericansR01AG072547 · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2025 to 2025
$5.2M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$2.0M
Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy AgingR01AG078964 · WASHINGTON UNIVERSITY · 2025 to 2025
$1.8M
Chinese language versions of the National Alzheimer's Coordinating Center's Uniform Data Set version 4: a linguistic and cultural adaptation studyR01AG083840 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$1.3M
Mechanisms of tau- and aging-induced neurological dysfunction: Focus on the nucleusR01AG057896 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Bess Frost · 2022 to 2023
$1.2M
The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populationsR01AG080469 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$1.1M
Alzheimer's Disease associated pathology induced by neurotropic viral infectionR01AG076007 · UPSTATE MEDICAL UNIVERSITY · 2025 to 2025
$572k
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nilton Custodio, Agustin M. Ibanez · 2023 to 2023
$513k
ADRC Developmental GrantAlzheimer's AssociationAlzheimer's Association and the Global Brain Health Institute GBHIALZUK-21-24204Alzheimer's Drug Discovery FoundationAlzheimer's Research UKAlzheimer's Society 522 AS-PhD-19a-010ANID (Agencia Nacional de Investigación y Desarrollo - Chilean National Agency for Research and Development) FONDAP (Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias) 15150012ANID (Agencia Nacional de Investigación y Desarrollo - Chilean National Agency for Research and Development)/FONDECYT (Fondo Nacional de Desarrollo Científico y Tecnológico) 1210176ANID (Agencia Nacional de Investigación y Desarrollo - Chilean National Agency for Research and Development)/FONDECYT (Fondo Nacional de Desarrollo Científico y Tecnológico) 1210195ANID (Agencia Nacional de Investigación y Desarrollo - Chilean National Agency for Research and Development)/FONDECYT (Fondo Nacional de Desarrollo Científico y Tecnológico) 1220995ANID (Agencia Nacional de Investigación y Desarrollo - Chilean National Agency for Research and Development)/PIA (Programa de Investigación Asociativa)/ANILLOS ACT210096AstraZenecaBelfer Neurodegeneration ConsortiumBiogenBluefield ProjectBright FocusCARDS-NIHChan Zuckerberg InitiativeCNRS (Centre National de la Recherche Scientifique)Coins for Alzheimer's Research TrustCure Alzheimer's FundCurePSPDavos Alzheimer's Collaborative for the Healthcare SystemDenali TherapeuticsDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) EXC2145SyNergy-ID390857198Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) HO2402/18-1MSAomicsEisaiEli LillyEpstein Breakthrough Alzheimer's Research FundEU Joint Programme-Neurodegenerative Disease Research (JPND) 01ED2405AEU Joint Programme-Neurodegenerative Disease Research (JPND) INSTALZ_643417European Joint Programme on Rare Diseases (Improve-PSP)Fogarty International Center [FIC]Foundation for the National Institutes of HealthGCRF Networking Grant from the UK Academy of Medical SciencesGerald and Henrietta Rauenhorst (GHR) FoundationGerman Research FoundationGlaxoSmithKlineGlobal Brain Health InstituteGlobal Brain Health Institute/UCSF PHHE-GBHI-7030526Hevolution/AFARHoffman La RocheINSERM (Institut National de la Santé et de la Recherche Médicale)Ionis PharmaceuticalsJanssenJohn Fell FundKissick FoundationLICEND (Lille Centre of Excellence for Neurodegenerative Disorders)Life Molecular Imaging/ADDFMedical Research Council MR/R011567/1MesoScaleMétropole Européenne de Lille; University of Lille; FEDER; Research Foundation Flanders; Innovation Fund Denmark; Agence Nationale de la Recherche; Swedish Research Council; Medical Research Council; European Union's Horizon 2020MJFFNational Institute for Health Research (NIHR) NIHR203312National Science Foundation 2104854National Science Foundation Awards 2150298New Vision ResearchNIA NIH HHS R01 AG057234NIA NIH HHS R01 AG057896NIA NIH HHS R01 AG072547NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG078964NIA NIH HHS R01 AG080469NIA NIH HHS R01AG080469NIA NIH HHS R01 AG083840NIA NIH HHS R01AG083840NIA NIH HHS R01 AG21051NIA NIH HHS R21AG068757NIA NIH HHS R21 AG078505NIA NIH HHS U19 AG074865NIGMS (National Institute of General Medical Sciences) - Maximizing Investigators' Research Award (MIRA) for Early-Stage Investigators GM150716NIH HHS R01AG074584-01NIH HHS R01AG075900-01NIH HHS R01AG076007NIH HHS R01NS091329NIH HHS RF1NS123568NIH/NIA R01AG072547NIH/NIA U19AG074865NIH/NIA U19AG076581NIH/NINDSNINDS NIH HHS K08 NS112330Pratiksha TrustPSP AssociationRace Against Dementia Alzheimer's Research UK Fellowship 2022-2027Rainwater Charitable FoundationRainwater Charitable Foundation - Tau ConsortiumRockefeller PhilanthropiesSangamo TherapeuticsThe Bluefield Project to Cure Frontotemporal DementiaThe French National Research Agency (ANR - Agence Nationale de la Recherche) - Laboratory of Excellence (LabEx) programthe GSKThe Scientific and Technological Development Support Fund (FONDEF) ID20I10152The Scientific and Technological Development Support Fund (FONDEF) ID22I10029the Takeda CW2680521UK Dementia Research InstituteUK Royal Society/African Academy of Sciences FLAIR FCG/R1/201034UK Royal Society/African Academy of Sciences FLAIR FLR/R1/191813University of California San DiegoUniversity of SussexVeterans AffairsWellcome Trust
6 · The paper itself

Abstract

Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases. HIGHLIGHTS: The Tau2024 Global Conference presented updates and advances in tau research. Blood-based biomarkers offer specificity and longitudinal monitoring capabilities. There are a range of targetable mechanisms in the cascade of pathogenesis. International collaboration is vital to address disparities in tauopathies.

Indexed as

BiomarkersTauopathiesBrainHumanstau ProteinsBiomarkerstau ProteinsAlzheimer's diseaseneurodegenerative diseasetau disordertauopathiestau protein

Identifiers

PMID40437880
PMCPMC12120264

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.