ArticleFrontiers in public health2025
Association between the systemic immune-inflammatory index and the immune response after hepatitis B vaccination: a cross-sectional analysis of NHANES data.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Systemic Inflammation and the Persistence of Vaccine-Induced Hepatitis B Immunity in Healthcare Workers.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
- Immunometabolic determinants of hepatitis B vaccine seroprotection among Ethiopian adults.Scientific reports · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
Aim: Our research aimed to investigate the relationship between the systemic immune-inflammatory index (SII) and the immunological response to hepatitis B vaccination. Methods: We collected data from the National Health and Nutrition Examination Survey database from 2007 to 2018. To examine the association between the SII and immunological response, we conducted weighted multiple regression analysis and subgroup analysis. Furthermore, we utilized restricted cubic splines (RCSs) to analyze the linear relationship between the two variables. Results: In our study, we included a total of 6,123 patients, of whom 2,770 tested positive for hepatitis B antibodies. Multivariate logistic regression analysis indicated that, after controlling for all measured factors, a high level of the SII was inversely associated with the presence of antibodies following three doses of the hepatitis B vaccine (OR = 0.8661, 95% CI = 0.7577-0.9899, Conclusion: This cross-sectional study revealed a strong association between low antibody production following hepatitis B vaccination and the SII. However, this cross-sectional study could not establish a causal relationship between the two variables. Therefore, further experimental verification is necessary to confirm the correlation observed in our study.
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