Evidence map›Paper›PMID 40438114›Full record

ArticleFrontiers in immunology2025

Olverembatinib (HQP1351)-based therapy in adults with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia in blast phase: results from a real-world study.

Ziyu Wen, Zhi Liu, Xu Ye, Zhiping Fan, Ren Lin, Fen Huang, Li Xuan, Xiaofang Li, Hua Jin, Min Dai and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. [Treatment strategies and prognostic factors for relapsed childhood acute lymphoblastic leukemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  2. Review
  3. Article
  4. How I treat Ph+ acute lymphoblastic leukemia.Future oncology (London, England) · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ziyu WenDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhi LiuDepartment of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Xu YeDepartment of Hematology, Second Affiliated hospital of Guangzhou Medical University, Guangzhou, China.
Zhiping FanDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ren LinDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fen HuangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li XuanDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaofang LiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hua JinDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Min DaiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jing SunDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xuan ZhouDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qiang WangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaoli LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qifa LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hongsheng ZhouDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Na XuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (R/R Ph Methods: Data were collected and analyzed to evaluate the efficacy and safety of olverembatinib-based therapy for advanced Ph Results: A total of 59 patients participated in the study, including 40 patients with Ph Conclusions: Olverembatinib-based therapy demonstrated significant efficacy and manageable toxicity in patients with advanced Ph

Indexed as

Blast CrisisLeukemia, Myelogenous, Chronic, BCR-ABL PositivePrecursor Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsAdultAgedDrug Resistance, NeoplasmFemaleFusion Proteins, bcr-ablHumansMaleMiddle AgedPhiladelphia ChromosomeRecurrenceTreatment OutcomeYoung AdultFusion Proteins, bcr-ablProtein Kinase Inhibitorsacute lymphoid leukemiablast phasechronic myeloid leukemiaHQP1351olverembatinibPh+Philadelphia chromosome positive

Identifiers

PMID40438114
PMCPMC12116509

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.