ArticleNeurophotonics2025
Repetitive transcranial magnetic stimulation increases synaptic plasticity of cortical axons in the APP/PS1 amyloidosis mouse model.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The Potential Use of Matrix Metalloproteinases in Alzheimer's Disease Therapy.Journal of clinical medicine · 2026Review
- Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation.Frontiers in synaptic neuroscience · 2026Article
- Repetitive transcranial magnetic stimulation increases synaptic plasticity of cortical axons in the APP/PS1 amyloidosis mouse model.Neurophotonics · 2025Article
- Introduction to the Special Issue "Understanding Brain Disease with Live Imaging".Neurophotonics · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Growing evidence highlights the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) in diseases causing dementias such as Alzheimer's disease (AD). However, individual responses to rTMS are variable, and its underlying neural mechanisms are not fully understood. Aim: As synaptic dysfunction is one of the key mechanisms associated with cognitive deficits in dementia, we investigated the effect of rTMS on cortical synapses using an APP/PS1 amyloidosis mouse model of AD crossed with fluorescent reporters linked to the Thy-1 promoter. Approach: Using Results: We found both types of axonal boutons preserved the overall number of their synaptic outputs in wild type (WT) and APP/PS1 groups, pre- and post-stimulation. Both synapse types also showed a significantly reduced dynamic fraction in APP/PS1 compared with WT axons pre-stimulation. Following stimulation, the TB, but not EPB, dynamic fraction increased in both WT and APP/PS1 groups. Conclusions: This suggests possible mechanisms of rTMS action that are cell type-specific and, together with previous findings of improved functional performance, present a potential clinical avenue for rTMS in the management of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.