Evidence map›Paper›PMID 40438247›Full record

ArticleVeterinary oncology (London, England)2025

Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells.

M D Wallace, M E Herrtage, R Gostelow, L Owen, L Rutherford, K Hughes, A Denyer, B Catchpole, C A O'Callaghan, L J Davison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M D WallaceDepartment of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.
M E HerrtageDepartment of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.
R GostelowDepartment of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.
L OwenDepartment of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.
L RutherfordDepartment of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.
K HughesDepartment of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.
A DenyerDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, Herts AL9 7 TA UK.
B CatchpoleDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, Herts AL9 7 TA UK.
C A O'CallaghanCentre for Human Genetics, University of Oxford, Oxford, UK.
L J DavisonDepartment of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine malignant insulinoma is a rare, highly metastatic and life-threatening neuroendocrine tumour of pancreatic beta cells. To map the single-cell transcriptomic landscape of canine insulinoma for the first time, transcriptomic profiles of 5,532 cells were captured from two spontaneous insulinomas (Patient 1 and 2) and one associated metastasis (Patient 2) in two Boxer dogs. Distinct cancer, endocrine, and immune cell populations were identified. Notably, all three tumour samples contained two transcriptionally distinct insulin-expressing tumour cell populations (INS Supplementary Information: The online version contains supplementary material available at 10.1186/s44356-025-00026-3.

Indexed as

BoxercanineEGR1insulinomaP53scRNA-seq

Identifiers

PMID40438247
PMCPMC12106163

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.