ReviewAnnals of translational medicine2025
Effect of isometric resistance exercise on blood pressure in normotensive adults: a systematic review of randomized clinical trials.
Review in Annals of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of relative handgrip strength and back muscle strength on the incidence of hypertension: 18-year follow-up in a population-based cohort study.Journal of human hypertension · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Isometric resistance exercise (IRE), characterized by static muscle contractions, has demonstrated potential in reducing blood pressure (BP). A meta-analysis revealed significant reductions in systolic (SBP) (6 mmHg), diastolic (DBP) (3 mmHg) and mean (3 mmHg) blood pressure. Although the effects of IRE in hypertensive individuals are known, its impact in normotensive adults is still poorly studied. This study evaluates IRE as a preventive strategy for hypertension. The objective of this study is to describe the effect of IRE on BP in normotensive adults. Methods: A systematic review registered with PROSPERO (CRD42024496749) was carried out using the PubMed, Virtual Health Library (VHL), Web of Science, Scopus, and Physiotherapy Evidence Database (PEDro). The descriptors "Resistance Training", "Isometric Exercise" and "Blood Pressure" were used. Randomized clinical trials investigating IRE in normotensive adult individuals were included, assessing the outcomes of SBP, DBP and/or mean arterial pressure (MAP). There were no restrictions on the period of publication. The risk of bias was assessed using the PEDro scale. Results: A total of 3,195 articles were identified, but only 5 were included in the review. The included studies, published between 2000 and 2022, had a parallel design and involved 142 normotensive, sedentary or regularly active volunteers aged between 19 and 34 years old. The exercise protocols for the experimental group consisted of IRE at an intensity of 20% to 34% of maximum voluntary contraction, 4 sets of 2 to 3 minutes each, with rest intervals of 2 to 3 minutes, performed 2 to 5 times a week for 3 to 8 weeks. IRE led to a significant reduction in SBP, DBP and MAP. The main mechanisms associated with this reduction were the release of vasodilator substances, a reduction in oxidative stress and an improvement in autonomic balance. All the studies included had moderate to high methodological quality. Conclusions: IRE reduces systolic, diastolic and MAP in normotensive individuals.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.