Evidence mapPaperPMID 40438874Full record

ArticleOncology letters2025

Rechallenge of anti-PD-1 antibody combined with chemotherapy shows promising efficacy in the treatment of advanced metastatic hepatocellular carcinoma: A case report.

Xiang Tan, Le Kang, Hao Chen, Xingyan Liu, Chi Du

Abstract readCase Reports
In one paragraph

Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiang TanDepartment of Hematology and Oncology, The People's Hospital of An'yue, Ziyang, Sichuan 642350, P.R. China.
Le KangDepartment of Hematology and Oncology, The People's Hospital of An'yue, Ziyang, Sichuan 642350, P.R. China.
Hao ChenDepartment of Hematology and Oncology, The People's Hospital of An'yue, Ziyang, Sichuan 642350, P.R. China.
Xingyan LiuDepartment of Hematology and Oncology, The People's Hospital of An'yue, Ziyang, Sichuan 642350, P.R. China.
Chi DuDepartment of Oncology and Hematology, The People's Hospital of Dujiangyan, Chengdu, Sichuan 611132, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report presents the case of a 53-year-old man who was diagnosed with hepatocellular carcinoma and developed lung metastasis after undergoing surgery and interventional treatment. The lung metastasis progressed multiple times while the patient was undergoing successive treatments with Lenvatinib, Apatinib combined with Camrelizumab and Regorafenib. Eventually, a positive response was achieved with Tislelizumab combined with Xelox. The patient has been receiving Tislelizumab combined with Xelox for 23 months and has maintained a complete response to treatment. This case indicates that combining immune rechallenge with chemotherapy is beneficial for metastatic hepatocellular carcinoma.

Indexed as

chemotherapyhepatocellular carcinomaimmune checkpoint inhibitorslung metastasistislelizumab

Identifiers

PMID40438874
PMCPMC12117356

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.