Evidence mapPaperPMID 40439217Full record

ArticleEnvironmental science & technology2025

Microbial Dysbiosis in the Lung and Gut in Response to Inhalable Particulate Matters in Pneumoconiosis Patients and Animals.

Huimin Ma, Zheng Dong, Xu Zhang, Ning Li, Conghe Liu, Xi Zhou, Jin He, Juan Ma, Shuping Zhang, Haidong Kan and 1 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. TiOInternational journal of molecular sciences · 2026
    Article
  3. Bacillus velezensis alleviates PMAnimal microbiome · 2026
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huimin MaMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.ORCID 0000-0003-1817-0625
Zheng DongMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.ORCID 0009-0008-5210-7455
Xu ZhangMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.
Ning LiMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.
Conghe LiuMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.
Xi ZhouShandong Academy of Occupational Health and Occupational Medicine, Occupational Diseases Hospital of Shandong First Medical University, Jinan, Shandong 250062, P. R. China.
Jin HeShandong Academy of Occupational Health and Occupational Medicine, Occupational Diseases Hospital of Shandong First Medical University, Jinan, Shandong 250062, P. R. China.
Juan MaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China.
Shuping ZhangMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.ORCID 0000-0003-1586-0559
Haidong KanSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, P. R. China.ORCID 0000-0002-1871-8999
Sijin LiuMedical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P. R. China.ORCID 0000-0002-5643-0734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumoconiosis is a progressive and life-threatening fibrotic lung disorder caused by the prolonged deposition of inhaled particulate matters (PMs); thus far, no cure is available. Emerging evidence has suggested that the resulting disordered respiratory microbiome is caused by disturbed lung architecture and homeostasis responding to inhalable PMs. Lung microbiome dysbiosis also contributes to injury to the lung and distant organs, such as the intestine, through the lung-gut axis. Current studies on the microbiome-disease interplay are still in their infancy, and sufficient understanding of microbial heterogeneity in pathological processes is lacking. Here we investigated the microbiome in the lung and gut of patients with pneumoconiosis in comparison to healthy individuals. Our findings indicated reciprocal causation between lung injuries and microbial dysbiosis under particle exposure; pulmonary

Indexed as

DysbiosisGastrointestinal MicrobiomeLungParticulate MatterPneumoconiosisAnimalsHumansMaleMicrobiotaMiddle AgedParticulate MatterInhalable particulate matterslung−gut axismicrobial dysbiosispneumoconiosissystemic inflammation

Identifiers

PMID40439217
PMCPMC12164263

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.