ArticleAsian Pacific journal of cancer prevention : APJCP2025
In Silico Analysis Revealed a Role for NUSAP1 in Lung Adenocarcinoma through E2F1/hsa-let-7b-5p/lncRNA-TMPO-AS1.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- KRT23 promotes proliferation invasion and metastasis of gastric cancer through epithelial-mesenchymal transition mediated by the PI3K/AKT/mTOR signaling pathway.Translational cancer research · 2025Article
- Long noncoding RNA TMPO-AS1 upregulates chromosomal passenger complex expression to promote cell proliferation in lung cancer via sponging microRNA let-7b-5p.Cell division · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNucleolar and spindle-associated protein 1 (NUSAP1) is crucial for chromosomal segregation and spindle assembly, its expression correlates with high morbidity and mortality rates, necessitating better understanding of prognosis-related networks.
methodsThe study used databases like KM Plotter, TNMplot, UALCAN, OncoMX, GEPIA2, OncoDB, ENCORI, TIMER 2.0, CancerSEA, miRNet, CellTracer, TISIDB, GSCA, and the Enrichr database to analyze NUSAP1 expression in lung cancer tumors and normal tissues.
resultsThe NUSAP1 gene is overexpressed in both adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). However, LUAD has a poor prognosis for overall survival (OS) (HR = 1.94), first progression (FP) (HR = 1.96), and post-progression survival (PPS) (HR = 1.48), while LUSC showed no significant data. High NUSAP1 expression is significantly associated with adenocarcinoma smoker patients. The study also found a strong correlation between lncRNA-TMPO-AS1 overexpression and poor OS prognosis in LUAD smokers, a negative relationship between miRNA hsa-let-7b-5p and TMPO-AS1/E2F1/NUSAP1 expression, and a positive correlation between S and M phase cell cycle checkpoints, tumor infiltrating CD4 immune cells, and NUSAP1 expression in lung adenocarcinoma.
conclusionSmokers with lung adenocarcinoma have worse prognoses due to higher E2F1, NUSAP1, and TMPO-AS1 levels, possibly due to TMPO-AS1 sponge formation with hsa-let-7b-5p.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.