Evidence map›Paper›PMID 40439409›Full record

ArticlemSystems2025

Chemical proteomics enhances the understanding of 2AA stress in

Dominik Schum, Michaela K Fiedler, Wangchen Shen, Stephan A Sieber, Diana M Downs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dominik Schum *School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Bavaria, Germany.
Michaela K Fiedler *School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Bavaria, Germany.
Wangchen ShenDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.
Stephan A SieberSchool of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Bavaria, Germany.ORCID 0000-0002-9400-906X
Diana M DownsDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-1564-6205

Funding

Rid family members neutralize endogenous metabolic stressorsR01GM095837 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DOWNS, DIANA M. · 2011 to 2023
$3.7M
Analysis of Metabolic Stress and Functional Integration in ProkaryotesR35GM153189 · NIGMS · UNIVERSITY OF GEORGIA · PI Diana M. Downs · 2024 to 2026
$1.0M
NIGMS NIH HHS R01 GM095837NIGMS NIH HHS R35 GM153189NIH HHS R35GM153189NIH HHS RO1GM095837
6 · The paper itself

Abstract

Pyridoxal 5'-phosphate (PLP) is an essential cofactor for enzymes that catalyze diverse reactions in central metabolism. 2-Aminoacrylate (2AA) is a reactive enamine and an obligate catalytic intermediate in some PLP-mediated reactions. In the absence of the enamine/imine deaminase RidA, IMPORTANCE: Loss of RidA homologs results in 2-aminoacrylate stress in

Indexed as

ProteomicsSalmonella entericaStress, PhysiologicalBacterial ProteinsClick ChemistryProteomePyridoxal PhosphateBacterial ProteinsProteomePyridoxal Phosphate2-aminoacrylatechemical proteomicsPLPpyridoxal-phosphate-dependent enzymesRidA

Identifiers

PMID40439409
PMCPMC12172467

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.