Evidence map›Paper›PMID 40439816›Full record

ArticleMedical & biological engineering & computing2025

Abnormal phase-amplitude coupling in patients with first-episode schizophrenia during the auditory steady-state response and resting states.

Jie Zhang, Xiong Jiao, Junjie Wang, Zhenying Qian, Yingchan Wang, Xiaochen Tang, Gai Kong, Junfeng Sun, Jijun Wang, Yingying Tang

Abstract read
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In one paragraph

Article in Medical & biological engineering & computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie ZhangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xiong JiaoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Junjie WangInstitute of Mental Health, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.
Zhenying QianShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
Yingchan WangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
Xiaochen TangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
Gai KongShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
Junfeng SunSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jijun WangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China. jijunwang27@163.com.
Yingying TangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China. yytang@smhc.org.cn.

Funding

National Key R&D Program of China 2022YFC3601200National Natural Science Foundation of China 61976136National Natural Science Foundation of China 81871050National Natural Science Foundation of China 81971251National Natural Science Foundation of China 82151314National Natural Science Foundation of China 82171497Science and Technology Commission of Shanghai Municipality 20ZR1448600Science and Technology Commission of Shanghai Municipality 21ZR1481500Shanghai Talented Youth Program and Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support 20191836Specific Project of Shanghai Jiao Tong University 2022XYJG0001-01-21STI2030-Major Projects 2022ZD0212800
6 · The paper itself

Abstract

The auditory steady-state response (ASSR) is a robust index for schizophrenia. Abnormal phase-amplitude coupling (PAC) in schizophrenia might be influenced by the confounding factors of illness stages and antipsychotic treatments. To exclude the effects of confounding factors, we examined abnormal PAC in antipsychotic-naïve patients with first-episode schizophrenia (FES) during the ASSR. 67 FES and 84 healthy controls (CON) were recruited and their EEG data were collected during the 20 Hz ASSR, 30 Hz ASSR, 40 Hz ASSR, and resting states. All the possible PAC patterns at Fz were compared between FES and CON, and the electrodes of abnormal PACs were explored. Results showed that FES had significantly higher beta-high gamma PAC at the prefrontal cortex and lower theta-low gamma PAC at the fronto-central cortex than CON during all the three ASSR blocks but not in the Resting block. FES showed lower correlations of PAC values between any two of the ASSR blocks than CON. Beta-high gamma PAC was negatively correlated with the cognitive scores of visual learning and attention, while theta-low gamma PAC was positively correlated with the score of symbol coding. Abnormal PAC of FES in specific brain regions may provide electrophysiological biomarkers for abnormal circuits.

Indexed as

Evoked Potentials, AuditoryRestSchizophreniaAdultCase-Control StudiesElectroencephalographyFemaleHumansMaleYoung AdultAntipsychotic-naiveAuditory steady-state responseElectroencephalographyFirst-episode schizophreniaPhase-amplitude coupling

Identifiers

PMID40439816

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.