Evidence map›Paper›PMID 40439848›Full record

ArticleAnnals of nuclear medicine2025

Dynamic expression of the myocardial sigma-1 receptor after doxorubicin cardiomyopathy using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5 V) imaging.

Zhuoqing Chen, Hiroshi Wakabayashi, Hiroshi Mori, Tomo Hiromasa, Xue Zhang, Takashi Kozaka, Kazuma Ogawa, Seigo Kinuya, Junichi Taki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhuoqing ChenDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Hiroshi WakabayashiDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan. wakabayashi@staff.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0002-4942-6470
Hiroshi MoriDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Tomo HiromasaDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Xue ZhangDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Takashi KozakaDivision of Probe Chemistry for Disease Analysis, Research Center for Experimental Modeling of Human Disease, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Kazuma OgawaGraduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa, Ishikawa, Japan.
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Junichi TakiDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.

Funding

Grant-in-Aid for Scientific Research (C) 20K08047JST SPRING JPMJSP2135
6 · The paper itself

Abstract

objectiveWe aimed to evaluate the expression of the intensity and distribution of the sigma-1 receptor (σ1R) demonstrated by radiolabeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) in a rat model of doxorubicin-induced cardiotoxicity.

methodsWistar rats received doxorubicin (DOX; 2 mg/kg/week) as an intraperitoneal injection. Gated

resultsNo rats died during DOX injections, until eight weeks. The left ventricular cavity volume increased compared to before DOX injection at five weeks after DOX injection. At seven weeks post-DOX injection, the ejection fraction decreased compared with that before the injection. DMSA scintigraphy revealed that renal function decreased significantly after seven weeks. In the post-mortem tissue counting study,

conclusionThe present study confirmed the expression pattern of σ1R expression after DOX injection. A decrease in σ1R expression detected using

Indexed as

CardiomyopathiesDoxorubicinGene Expression RegulationIodine RadioisotopesMyocardiumPiperidinesReceptors, sigmaAnimalsMaleRatsRats, WistarSigma-1 ReceptorTissue DistributionTomography, Emission-Computed, Single-PhotonDoxorubicinIodine RadioisotopesPiperidinesReceptors, sigmaSigma-1 ReceptorDoxorubicin-induced cardiotoxicityMolecular imagingOI5 VSigma-1 receptorTGF-β1

Identifiers

PMID40439848
PMCPMC12378282

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.