ArticleMolecular neurobiology2025
Identification of NLRP3 Inflammasome-associated Biomarkers by Integrated Bioinformatics Analysis in Neuropathic Pain.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain (NP) is a chronic disease due to nerve injury, viral infections, etc. Inflammatory factors are a key part of its pathological mechanism, and NLRP3 has been widely studied in other diseases; however, its study in NP is still scarce. We analyzed genes differentially expressed in NP and normal samples using public databases. Six key markers were screened by WGCNA and a machine learning approach. The research value of key markers in NP was further verified by correlation analysis, expression analysis and validation, regulatory network construction, and molecular docking. Our results identified six reliable key markers: Lyz2, Fcgr4, Gm2a, Sumf1, Zbtb7a, and Treml2. After correlation analysis and molecular functional similarity analysis, it was concluded that Lyz2 might be a key marker of NLRP3 with greater potential in NP. Our study may find new targets for NP.
Indexed as
Identifiers
40439855What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.