Evidence map›Paper›PMID 40439989›Full record

ArticleJournal of assisted reproduction and genetics2025

Influence of combined oral contraceptive pill before PPOS protocol on egg donors and recipients' outcomes: an international multicenter retrospective study.

Sara Maggi, Silvia Bontà, Antonio Forgiarini, Greet Lammens, Simona Franzò, Giulia Zamagni, Lodovico Parmegiani, Gabriella Zito, Giuseppe Ricci, Luis Alberto Quintero Espinel

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara MaggiGametia-Next Fertility Valencia, Valencia, Spain. sara.maggi923@gmail.com.ORCID http://orcid.org/0009-0009-2016-0582
Silvia BontàGametia-Next Fertility Valencia, Valencia, Spain.
Antonio ForgiariniGametia-Next Fertility Valencia, Valencia, Spain.
Greet LammensGametia-Next Fertility Valencia, Valencia, Spain.
Simona FranzòDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Giulia ZamagniClinical Epidemiology and Public Health Research Unit - Institute for maternal and child health IRCCS "Burlo Garofolo", Trieste, Italy.
Lodovico ParmegianiNext Fertility Gynepro - NextClinics International, Bologna, Italy.
Gabriella ZitoInstitute for Maternal and Child Health- Burlo Garofalo, SC Fisiopatologia della Riproduzione e PMA, Trieste, Italy.
Giuseppe RicciDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Luis Alberto Quintero EspinelGametia-Next Fertility Valencia, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to evaluate whether using a combined oral contraceptive pill (COCP) pre-treatment before controlled ovarian hyperstimulation (COH) may negatively influence ovarian response in donors and treatments outcomes in recipients when a progestin-primed ovarian stimulation (PPOS) protocol is used in oocyte donation treatments.

methodsMulticenter retrospective cohort study evaluating outcomes of 397 COH cycles in oocyte donors, with and without COCP pre-treatment. The retrieved oocytes were used for 216 oocyte donation cycles in recipients.

resultsIn donors, the No-COCP group obtained a higher number of total, MII, and useful oocytes, similar stimulation days, total FSH dose used, and cancellation rate due to low response, while the COCP group showed significantly higher cancellations for low LH levels, indicative of long-lasting pituitary suppression COCP related. In recipients, both groups showed similar fertilization rate and blastocyst formation rate. Miscarriage rate (MR) was significantly higher in the COCP group, while higher implantation rate, ongoing pregnancy rate (OPR), and live birth rate (LBR) were obtained in the No-COCP group.

conclusionsDonor response to COH with PPOS protocol appears to be negatively influenced by COCP pre-treatment, with implications for oocyte donation treatment outcomes in recipients, including higher MR and lower OPR/LBR. Further studies are needed to confirm these findings.

Indexed as

Contraceptives, Oral, CombinedOocyte DonationOvulation InductionProgestinsAbortion, SpontaneousAdultBirth RateEmbryo TransferFemaleFertilization in VitroHumansLive BirthOocyte RetrievalOocytesPregnancyPregnancy RateContraceptives, Oral, CombinedProgestinsCombined oral contraceptivesOocyte donationPPOS protocolPregnancy outcomesVitrified oocytes

Identifiers

PMID40439989
PMCPMC12356787

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.