ArticlePLoS neglected tropical diseases2025
Cognitive impairment in Chagas disease patients in Brazil, 2007-2021: A cross-sectional study.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Bridging the Nervous-Endocrine System and Immune Response, in Human Chagas Disease Pathology.Neuroimmunomodulation · 2025Review
- Neurochagas: Experimental and human literature of an uncommon entity (Review).Medicine internationalReview
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Authors and funding
20 authors.
Funding
Abstract
introductionChagas Disease (CD) is frequently associated with heart failure (HF). Cognitive impairment is reported, but whether it results from CD or is a nonspecific symptom of HF is unknown. We aimed to compare cognitive function of HF patients with or without CD.
methodsMulticenter cross-sectional study of HF patients. Investigators blinded to the etiology of HF evaluated global cognition and domains of memory, executive and visuospatial function. Logistic regression tested the association between CD and cognitive impairment (Z-score < -1.5) in each domain adjusted for age, sex, educational level and left ventricular ejection fraction.
resultsWe recruited 518 patients, 250 (48.3%) with CD. Cognitive impairment was more common in CD vs. non-CD patients (27.1% vs 13.1%, p < 0.001), mostly in memory (10.4% vs 5.0%, p = 0.022) and visuospatial function (45.2% vs 29.6%, p < 0.001). In the multivariable analysis, CD remained associated with global cognitive impairment (odds ratio 1.90; 95% CI 1.13-3.21, p = 0.016) and visuospatial function impairment (OR 1.56; 95% CI 1.02-2.39, p = 0.039). DISCUSSION: Chagas disease is associated with cognitive impairment independently of heart failure severity, suggesting other competing mechanisms.
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