ArticleInternational journal of hygiene and environmental health2025
Association of urinary arsenic concentrations with inflammation: overall and by folate intake, body mass index, and gender.
Article in International journal of hygiene and environmental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Arsenic exposure, arsenic metabolism, and plasma lipidome in relation to type 2 diabetes and glycemic traits: a lipidome-wide association study.Journal of advanced research · 2026Article
- Evaluation of the Association Between Carrageenan and Systemic Inflammation: Results From the National Health and Nutrition Examination Survey.Molecular nutrition & food research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundInorganic arsenic (iA) exposure is associated with increased risk of lung, bladder, and skin cancer, as well as cardiovascular disease and diabetes. C-reactive protein (CRP), a measurement of inflammation, has been associated with these conditions. As the relationship between urinary arsenic and CRP remains unclear, we aim to determine if there is an association and to examine effect modification by dietary and lifestyle factors.
methodsThe study includes 5761 adults, ages 25+, over four survey cycles (2005-2006, 2007-2008, 2009-2010, and 2015-2016), surveyed as part of the National Health and Nutrition Examination Survey (NHANES) and included in the laboratory subsample. Survey-weighted multivariable linear regression was used to determine the association between log-transformed arsenic concentrations (∑As, monomethylarsonate [MMA], and dimethylarsinate [DMA], and primary and secondary methylation indices [PMI, SMI]) and log-transformed CRP. Models were stratified by gender, body mass index (BMI), folic acid supplement use, and dietary folate intake.
resultsThree forms of urinary arsenic were associated with statistically significant lower levels of CRP (∑As: -3.06 %, MMA: -2.34 %, DMA: -2.10 %, per 25 % increase in arsenic concentration). The association between SMI and CRP varied by gender (p-interaction: <0.01) and dietary folate intake (p-interaction: 0.04).
conclusionsThe inverse association between urinary arsenic concentrations and CRP was unexpected, highlighting a need to better characterize effects of iAs at low levels of exposure. Effect modification by dietary folate intake suggests that folate may affect the secondary methylation pathway, however, more research is needed to understand the role that folic acid plays in arsenic methylation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.