Evidence map›Paper›PMID 40441702›Full record

ArticleRenal failure2025

The hidden danger: prolonged exposure to inorganic contaminants and kidney health in adolescents.

Xiaoran Xue, Zaiqiu Zhang, Marady Hun, Min Wen, Mingyi Zhao, Qingnan He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoran XueDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Zaiqiu ZhangDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Marady HunDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Min WenDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Mingyi ZhaoDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Qingnan HeDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research on the impact of prolonged exposure to inorganic contaminants, such as perchlorate, nitrate, and thiocyanate (PNT), on the kidney health of individuals in the 12 ∼ 19 age range is lacking. We analyzed data from the United States National Health and Nutrition Examination Survey (NHANES) over the period 2005-2016 to investigate the linear relationship between chronic kidney disease (CKD)-related parameters and PNT exposure levels, and to explore population heterogeneity from multiple aspects. Weighted multiple regression analysis estimated the independent associations between water or urine exposure indicators and CKD-related parameters. We utilized stratified subgroup analysis and smooth linear fitting as supplements. Lower estimated glomerular filtration rate (eGFR) (non- or new-creatinine (CR)-adjusted), albumin-to-creatinine ratio (ACR), and blood urea nitrogen (BUN) were associated with urine PNT exposure. Water exposure may not be the primary source of PNT exposure. Females had a stronger negative association between nitrate and eGFR after non- or new-CR adjustment. With the most demographic heterogeneity, perchlorate affected eGFR, ACR, and BUN. Our findings associated urinary PNT exposure with altered renal parameters (eGFR, ACR, BUN) in adolescents aged 12-19, suggesting potential environmental health implications that warrant further investigation.

Indexed as

Environmental ExposureKidneyNitratesPerchloratesRenal Insufficiency, ChronicThiocyanatesAdolescentBlood Urea NitrogenChildCreatinineFemaleGlomerular Filtration RateHumansMaleNutrition SurveysUnited StatesCreatinineNitratesperchloratePerchloratesthiocyanateThiocyanatesadolescentschildrenCKDnitrateperchloratepollution

Identifiers

PMID40441702
PMCPMC12123952

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.