SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Assessment measures for chemotherapy-induced peripheral neuropathy among pediatric oncology patients: an updated systematic review.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Folic acid deficiency in cancer therapy: a review of chemotherapy-induced malabsorption and supportive care strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Cross-cultural adaptation and validation of the Pediatric Chemotherapy-Induced Neuropathy (P-CIN) using a patient-reported outcome measure for Chinese pediatric oncology patients.Health and quality of life outcomes · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo update the systematic review of assessment tools on chemotherapy-induced peripheral neuropathy (CIPN) for pediatric oncology patients based on the evidence available after the published review in 2020. DATA SOURCES: Seven English-language databases (PubMed, CINAHL, PsycINFO, EMBASE, the Cochrane Central Register of Controlled Trials, Scopus and Web of Science) were searched for studies published from Nov 9, 2018, to May 20, 2024. STUDY SELECTION: Studies that contained subjects who had a cancer diagnosis and were aged under 18 years and discussed the development of a tool to measure CIPN or assessed all test items and response categories for CIPN were included. DATA EXTRACTION AND SYNTHESIS: Data were screened and extracted independently using predesigned tables. The quality of each study was assessed based on Joanna Briggs Institute's critical appraisal tools for analytical cross-sectional studies and case control studies. The quality of identified instruments for CIPN was evaluated by the modified version of Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool.
resultsA total of 5 studies (with 633 patients) were included in the systematic review. Only one study was rated as high quality. We newly identified two patient-reported outcome measures (PROMs), one objective assessment and a pain scale, and three new studies about the previous identified CIPN assessment measures. CONCLUSIONS AND RELEVANCE: Based on the current evidence, the pediatric-modified Total Neuropathy Score (ped-mTNS) and the Total Neuropathy Score-Pediatric Vincristine (TNS-PV) are still the two most appropriate tools for healthcare professionals to use in clinical settings. Our results also addressed the gap in existing literature by showing two newly PROMs for CIPN in pediatric oncology patients with acceptable quality. The combination of physician-based assessment tools and PROMs are recommended to evaluate the patients' CIPN-related symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.