Evidence map›Paper›PMID 40442749›Full record

ArticleBMC oral health2025

Initial periodontal therapy for seven patients with aplastic anemia and drug-induced gingival overgrowth: a case series report.

Xinxin Lv, Xue Yang, Xinying Lv, Jiaping Huang, Anna Dai, Lingling Jin, Hao Huang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Drug-induced gingival overgrowth: evaluation of an online survey.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinxin LvPeriodontology Specialty Clinic, Department of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
Xue YangSchool of Stomatology, Dalian Medical University, No.9, West Section Lvshun South Road, Dalian, 116044, China.
Xinying LvDepartment of Pathology, HangZhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310009, China.
Jiaping HuangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, , Cancer Center of Zhejiang University, Hangzhou, 310000, China.
Anna DaiStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, , Cancer Center of Zhejiang University, Hangzhou, 310000, China.
Lingling JinDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
Hao HuangDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China. dr.huangh@163.com.

Funding

Research and Development Project of Stomatology Hospital of Zhejiang University School of Medicine No.RD2022DLYB06Zhejiang Provincial Natural Science Foundation of China LQN25H140006
6 · The paper itself

Abstract

backgroundPatients with aplastic anemia are at increased risk of bleeding, which often limits conventional periodontal treatment. Although drug-induced gingival overgrowth is well-documented, its management in this high-risk population has not been thoroughly studied. CASE PRESENTATION: We respectively reviewed the cases of seven aplastic anemia patients (4 males, 3 females; aged 33-57) with cyclosporine-associated drug-induced gingival overgrowth who were treated with initial periodontal therapy (IPT) under hematologist supervision from May 2018 to October 2024. Within 1-6 months follow-up visit, 6 of 7 patients achieved complete resolution of gingival overgrowth. One patient with severe overgrowth and concurrent felodipine use required 15 months for full resolution. Two cases of postoperative bleeding were controlled by removing chronic inflammatory tissue. One patient experienced recurrence after discontinuing follow-up for 2 years. No infections occurred during treatment.

conclusionsIPT can safely and effectively treat severe drug-induced gingival overgrowth in patients with aplastic anemia. A maintenance therapy frequency of no less than once every three months is crucial to prevent recurrence in these patients.

Indexed as

Anemia, AplasticCyclosporineGingival OvergrowthImmunosuppressive AgentsAdultFemaleHumansMaleMiddle AgedCyclosporineImmunosuppressive AgentsAplastic anemiaCase series reportCyclosporine ADrug-induced gingival overgrowthInitial periodontal therapy

Identifiers

PMID40442749
PMCPMC12123831

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.