Evidence map›Paper›PMID 40442776›Full record

ArticleWorld journal of surgical oncology2025

High pathological tumor response associates with enhanced overall survival in HNSCC patients following neoadjuvant immunochemotherapy and surgery.

Yudong Ning, Yixuan Song, Han Li, Yuqin He, Shaoyan Liu, Yang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yudong NingDepartment of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, P.R. China.
Yixuan SongDepartment of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, P.R. China.
Han LiDepartment of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, P.R. China.
Yuqin HeDepartment of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, P.R. China.
Shaoyan LiuDepartment of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, P.R. China. shaoyan_liu@sina.com.
Yang LiuDepartment of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, P.R. China. liuyang@cicams.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the impact of the postoperative pathological remission status on the prognosis of patients who underwent surgery after neoadjuvant immunochemotherapy in head and neck squamous cell carcinoma (HNSCC).

methodsThis study retrospectively analyzed patients who participated in a clinical trial at our hospital. These patients received neoadjuvant pembrolizumab combined with platinum and taxane followed by surgery from March 1, 2021, to November 1, 2024. Clinical and pathological characteristics were collected. Cox regression analysis was used to analyze clinical and pathological characteristics by univariate and multivariate analysis, and Kaplan Meier (KM) survival curves were plotted to evaluate the associations of clinical and pathological characteristics with the progression free survival (PFS) and overall survival(OS). Propensity score matching (PSM) was used to level the baseline of clinical characteristics.

resultsThe study cohort consisted of a total of 62 patients. the PFS rate of the patients was 85.5%, and the OS rate was 87.1%. The follow-up period of the patients ranged from 4 to 41 months, with an mean follow-up time of 23.7 months. However, high pathological tumor response (PTR) was significantly associated with better OS (97.2% vs 70.8%) and was an independent prognostic factor ( hazard ratio 0.153; 95% Confidence interval 0.018 - 1.307, p = 0.046). Before and after PSM, patients with high PTR had a significantly longer OS than those without high PTR (p = 0.0258,0.0053).

conclusionOur study showed a strong OS improvement in patients who achieved high PTR after neoadjuvant immunochemotherapy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsHead and Neck NeoplasmsNeoadjuvant TherapySquamous Cell Carcinoma of Head and NeckAdultAgedAntibodies, Monoclonal, HumanizedBridged-Ring CompoundsFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateAntibodies, Monoclonal, HumanizedBridged-Ring CompoundspembrolizumabtaxaneTaxoidsImmune checkpoint inhibitorsNeoadjuvant immunotherapyOverall survivalPathological complete responsePathological tumor responsePrognosisProgression free survival

Identifiers

PMID40442776
PMCPMC12121144

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.