Evidence map›Paper›PMID 40443044›Full record

Trial reportPhysiological reports2025

Cardiopulmonary responses to acute exogenous ketosis at rest, and during submaximal and maximal exercise.

Christopher D Crabtree, Justen Stoner, Alex Buga, Bradley Robinson, Drew Decker, Ashwini Chebbi, Xavier El-Shazly, Emily Murphy, Aydan Jordan, Teryn Bedell and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christopher D CrabtreeDepartment of Radiology, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-7284-3048
Justen StonerDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Alex BugaDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Bradley RobinsonDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Drew DeckerDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Ashwini ChebbiDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Xavier El-ShazlyDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Emily MurphyDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Aydan JordanDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Teryn BedellDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Madison L KackleyDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Tyler McClureDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Yuchi HanDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Orlando P SimonettiDepartment of Radiology, The Ohio State University, Columbus, Ohio, USA.
Jeff S VolekDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.

Funding

U.S. Department of Defense (DOD) W81XWH-22-1-0867
6 · The paper itself

Abstract

Nutritional ketosis achieved through various methods in animals and humans has been shown to augment cardiac efficiency and function. However, this response during exercise has not been well characterized. Recreationally active adults (n = 12) completed a double blind, balanced, placebo-controlled, crossover study to examine the effects of bis-octanonyl (R)-1,3-butanediol (BO-BD) ingestion on cardiopulmonary function at rest and during a maximal oxygen consumption (V̇O

Indexed as

Butylene GlycolsExerciseKetosisRest3-Hydroxybutyric AcidAdultBlood GlucoseCross-Over StudiesDouble-Blind MethodExercise TestFemaleHeart RateHumansMaleOxygen ConsumptionYoung Adult3-Hydroxybutyric AcidBlood GlucoseButylene Glycolscardiopulmonaryexercise performanceketonesketosis

Identifiers

PMID40443044
PMCPMC12122769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.