Evidence map›Paper›PMID 40444012›Full record

ArticleOpen medicine (Warsaw, Poland)2025

Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3.

Jing Fang, Kunshan Li, Liyuan Zhang, Ying Zhang, Yifan Wang, Jing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing FangEndoscopy Clinic, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei, 066000, China.
Kunshan LiDepartment of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, China.
Liyuan ZhangDepartment of Stomatology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei, 066000, China.
Ying ZhangDepartment of Stomatology, The Third Hospital of Shijiazhuang City, Shijiazhuang, Hebei, 050011, China.
Yifan WangDepartment of Stomatology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, China.
Jing ZhangDepartment of Medical Periodical Press, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of interleukin-37 (IL-37) on oral cancer and its underlying mechanisms. Two oral cancer cell lines, HN13 and HSC-6, were employed in the study. Our findings reveal that IL-37 markedly inhibits cell viability and induces apoptosis in oral cancer cells. IL-37 attenuates the proliferation of oral cancer cells induced by lipopolysaccharide and tumor necrosis factor-alpha, while knockdown of

Indexed as

cell growthIL-37oral cancerSTAT3

Identifiers

PMID40444012
PMCPMC12120405

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.