Evidence map›Paper›PMID 40444021›Full record

ArticlePain reports2025

Sensory neuron-specific block of multifaceted sodium channels mitigates neuropathic pain behaviors of osteoarthritis.

Seung Min Shin, Brandon Itson-Zoske, Hao Xu, Hongfei Xiang, Fan Fan, Quinn H Hogan, Hongwei Yu

Abstract read
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seung Min ShinDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Brandon Itson-ZoskeDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Hao XuDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Hongfei XiangDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Fan FanDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Quinn H HoganDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Hongwei YuDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0003-3029-3644

Funding

Primary sensory neuron-targeted block of Cav3.2 for treatment of chronic neuropathic painR33NS116203 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI HOGAN, QUINN H, YU, HONGWEI · 2021 to 2022
$800k
Mechanism of dual Nav1.7 and Nav1.8 block by a NaV inhibitory peptideR21NS137014 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI YU, HONGWEI · 2024 to 2025
$446k
Schwann cell Piezo1 and pain sensationR21NS138704 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI YU, HONGWEI · 2024 to 2024
$429k
NINDS NIH HHS R21 NS137014NINDS NIH HHS R21 NS138704NINDS NIH HHS R33 NS116203
6 · The paper itself

Abstract

Objective: Multiple voltage-gated sodium channels (Na Methods: To test this hypothesis, we generated recombinant adeno-associated virus (AAV) encoding a potent Na Results: Expression of Na Conclusion: Together, these results support that (1) Na

Indexed as

Adeno-associated virusDorsal root gangliaOsteoarthritisPainPeripheral nervous systemSensory neuronsSodium channels

Identifiers

PMID40444021
PMCPMC12119052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.