ArticleBMJ public health2025
Case-crossover assessment of the modifying effects of home medication use on acute kidney-related morbidity due to elevated ambient heat exposure in Atlanta, GA, from 2013 to 2019.
Article in BMJ public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Elevated ambient temperatures increase the risk for acute kidney-related morbidity, and medication use may increase vulnerability to heat exposure. This study examines whether medication use, and combination medication use (ie, polypharmacy), modifies the risk for temperature-related volume depletion (VD) and acute kidney injury (AKI). Methods: This study uses patient-level emergency department (ED) visit data from four Atlanta-area hospitals during the warm season from 2013 to 2019. ED patient-visits who reported a medication were matched with up to five ED patient-visits without the medication. Medications included angiotensin converting enzymes and angiotensin receptor blockers (ACE/ARBs), anti-depressants, anti-convulsants, β-blockers, diuretics, non-steroidal anti-inflammatory drugs and statins. A case-crossover framework is used to estimate associations between daily maximum temperature, medication use and VD/AKI ED visits. Results: There were 14 635 VD and 18 716 AKI ED visits in this study. For a change in ambient temperature (lags 0-2) from the 50 Conclusion: Results show that both single and combined medication use are associated with elevated risk for VD and AKI during periods of elevated ambient temperature.
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