Evidence map›Paper›PMID 40444264›Full record

ArticleSleep advances : a journal of the Sleep Research Society2025

Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort.

Kathryn R Dalton, Vicky C Chang, Mikyeong Lee, Katherine Maki, Pedro Saint-Maurice, Vaishnavi Purandare, Xing Hua, Yunhu Wan, Casey L Dagnall, Kristine Jones and 9 more

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In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kathryn R DaltonImmunity Inflammation and Disease Branch, National Institute of Environmental Health Sciences, RTP NC, USA.
Vicky C ChangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mikyeong LeeImmunity Inflammation and Disease Branch, National Institute of Environmental Health Sciences, RTP NC, USA.
Katherine MakiTranslational, Biobehavioral, and Health Disparities Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Pedro Saint-MauriceChampalimaud Foundation, Lisbon, Portugal.
Vaishnavi PurandareDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Xing HuaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Yunhu WanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-6556-0602
Casey L DagnallDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kristine JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-1584-8920
Belynda D HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-4962-2711
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mitchell H GailDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephanie J LondonImmunity Inflammation and Disease Branch, National Institute of Environmental Health Sciences, RTP NC, USA.ORCID https://orcid.org/0000-0003-4911-5290
Emily VogtmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-1355-5593

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesThe microbiome is proposed as a contributor to the adverse health impacts from altered sleep. The oral microbiome is a multifaceted microbial community that influences many health functions. However, data on the relationship between sleep and the oral microbiome are limited, and no studies have incorporated lifestyle and environmental exposures.

methodsWithin a subset (N=1,139) of the NIH-AARP cohort, we examined the association between self-reported sleep duration and the oral microbiome via 16S rRNA gene amplicon sequencing. Statistical models were adjusted for demographic characteristics. Additional models examined the role of various lifestyle and neighborhood exposures on the sleep-oral microbiome association.

resultsCompared to participants reporting the recommended 7-8 hours average sleep duration (n=702), those reporting short sleep (6 or fewer hours, n=284) had consistently decreased within-sample oral microbial diversity [e.g. number of observed amplicon sequence variants difference -8.681, p-value=0.009]. Several bacterial genera were more likely to be absent in the short sleep group. We found a higher relative abundance of

conclusionsOur findings provide evidence for an association of short sleep duration with oral microbial diversity and composition. This suggests that oral bacteria may play a possible mechanistic role related to sleep health. Improved understanding of physiological pathways can aid in the design of interventions that may beneficially improve overall sleep health.

Indexed as

epidemiologyOral microbiomePopulation healthSleep duration

Identifiers

PMID40444264
PMCPMC12120444

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.