Evidence map›Paper›PMID 40444427›Full record

ArticleRNA biology2025

Dual synthesis pathways of scaRNA28 via intronic processing of transformation/transcription domain-associated protein transcripts and a novel independent transcription unit.

Keiichi Izumikawa, Tatsuya Shida, Hideaki Ishikawa, Sotaro Miyao, Takayuki Ohga, Masato Taoka, Yuko Nobe, Hiroshi Nakayama, Masami Nagahama

Abstract read
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In one paragraph

Article in RNA biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keiichi IzumikawaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose-shi, Japan.ORCID 0000-0001-7262-5403
Tatsuya ShidaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose-shi, Japan.
Hideaki IshikawaDepartment of Applied Biological Science & Global Innovation Research Organizations, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Sotaro MiyaoLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose-shi, Japan.
Takayuki OhgaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose-shi, Japan.
Masato TaokaDepartment of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan.
Yuko NobeDepartment of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan.
Hiroshi NakayamaBiomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
Masami NagahamaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose-shi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small Cajal body-specific RNAs (scaRNAs) are noncoding RNAs involved in the maturation of U-rich small nuclear RNAs. Except for a few that have their own transcription units, most scaRNA genes are embedded in introns and are predicted to be transcribed with host genes. Herein, we report that scaRNA28 is the first scaRNA with a dual synthesis pathway, and that this RNA is transcribed in an independent transcription unit (ITU) by RNA polymerase II while located in intron 2 of the transformation/transcription domain-associated protein (TRRAP) gene. We evaluated the scaRNA28 synthesis pathway using minigenes containing exon 2, intron 2, and exon 3 of

Indexed as

IntronsRNA, UntranslatedTranscription, GeneticExonsHumansPromoter Regions, GeneticRNA Polymerase IIRNA SplicingRNA Polymerase IIRNA, Untranslatedindependent transcription unitMYCnon-coding RNAscaRNAsnoRNA

Identifiers

PMID40444427
PMCPMC12150615

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.