Evidence map›Paper›PMID 40444456›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Unraveling Tissue-Specific Fatty Acid Biosynthesis and Inter-Tissue Crosstalk in Mice through Stable-Isotope Tracing Metabolomics.

Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng-Jiang Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. DietaryAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Beizi XingInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Ruohong WangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Tianzhang KouInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Wenbin LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Zheng-Jiang ZhuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.ORCID https://orcid.org/0000-0002-3272-3567

Funding

National Key R&D Program of China 2022YFC3400702National Natural Science Foundation of China 22425404Shanghai Basic Research Pioneer ProjectShanghai Key Laboratory of Aging Studies 19DZ2260400Shanghai Municipal Science and Technology Major ProjectStrategic Priority Research Program of the Chinese Academy of Sciences XDB39050700
6 · The paper itself

Abstract

Biosynthesis of free fatty acids (FFAs) in mammals is pivotal for metabolic homeostasis, yet a comprehensive understanding of tissue-specific biosynthesis and inter-tissue crosstalk of FFAs remains incomplete. In vivo stable-isotope tracing metabolomics is utilized to comprehensively measure FFA biosynthesis and inter-tissue crosstalk in mice. Systematically assessing tissue-specific biosynthesis of 13 FFAs across 15 tissues unveils dynamic spatial and temporal accumulation and redistribution of FFAs throughout the body. Employing an analytical framework to deconvolve mass isotopologue patterns, inter-tissue crosstalk is explored for saturated, polyunsaturated, and monounsaturated FFAs, and quantify communications of FFA (16:0) and FFA (18:0) between the liver and other tissues. Then, a decline in fatty acid biosynthesis in peripheral tissues but not in the brain of aged mice is observed, particularly evident in palmitic acid and monounsaturated fatty acids. These findings illuminate the complex interplay between tissue-specific fatty acid biosynthesis and the maintenance of metabolic homeostasis.

Indexed as

Fatty AcidsFatty Acids, NonesterifiedMetabolomicsAnimalsBrainIsotope LabelingLiverMaleMiceMice, Inbred C57BLFatty AcidsFatty Acids, Nonesterifiedfatty acid biosynthesisinter‐tissue crosstalkmass spectrometrymetabolomicsstable‐isotope tracing

Identifiers

PMID40444456
PMCPMC12376646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.