ArticlemBio2025
Microsporidian obligate intracellular parasites subvert autophagy of infected mammalian cells to promote their own growth.
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Microsporidia: evolution, infection mechanisms and host impact.Nature reviews. Microbiology · 2026Review
- Interplay between proteostasis pathways and innate immune responses inInfection and immunity · 2026Review
- Microsporidian Encephalitozoon hellem inhibits host mitophagy by inducing ERAD to degrade BNIP3L.PLoS pathogens · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Intracellular pathogens such as Microsporidia can interfere with host proteostasis pathways, including autophagy. While the manipulation of host autophagy has been demonstrated in a nematode-infecting species, and autophagic activity was also observed in tardigrade midgut infections, it remains unclear whether this strategy extends to mammalian-infecting Microsporidia. Here, we investigated interactions between host autophagy and two human-pathogenic Microsporidian species representing distinct evolutionary lineages. Using immunochemistry, super-resolution fluorescence microscopy, and modulation of autophagy via siRNA silencing and chemical agents, we show that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.