SynthesisJournal of pediatric gastroenterology and nutrition2025
Percutaneous transhepatic cholangiography and drainage for biliary strictures after pediatric liver transplantation.
Synthesis in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Percutaneous transhepatic cholangiography and drainage for biliary strictures after pediatric liver transplantation.Journal of pediatric gastroenterology and nutrition · 2025Pooled it
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesBiliary strictures (BS) remain frequent after pediatric liver transplantation (pLT) and best management practices are still lacking. This study systematically assesses efficacy of stricture treatment by percutaneous transhepatic cholangiography and drainage (PTCD).
methodsOnline databases were searched for studies on PTCD treatment of BS after pLT from the year 2000 to 2024. Efficacy and safety profile of PTCD were analyzed. Influence of various risk factors on outcome parameters was compared by meta-regression.
resultsTwenty-seven observational studies with 802 patients undergoing PTCD for BS met the inclusion criteria. Incidence of BS was 13.1% (95% confidence interval [CI]: 10.3-16.1) in 6543 patients reported who underwent pLT between 1989 and 2020. Overall efficacy of PTCD to achieve stricture resolution was 78.3% (95% CI: 66.5-80.4). Drainage duration longer or shorter than 109.1 days did not impact on achievement of resolution with efficacies of 76.5% (95% CI: 65.4-86.2) in short versus 75.1% (95% CI: 61.9-86.5, p = 0.87) in long drainage. Overall recurrence rate after stricture resolution was 16.0% (95% CI: 7.5-26.3). Drainage duration longer or shorter than 109.1 days did not affect recurrence rate which was 17.4% (95% CI: 3.3-37.3) in short versus 20.9% (95% CI: 14.0-28.5, p = 0.68) in long drainage duration. Overall rate of procedure-related complications was 9.9% (95% CI: 2.6-20.0, p = 0.99) and was not influenced by drainage duration.
conclusionsPTCD is efficient to treat BS after pLT. Drainage time does not impact efficacy, recurrence rate, and complication rate. Randomized trials are necessary to determine the best treatment protocol concerning drainage duration and intervals between interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.