Evidence map›Paper›PMID 40444524›Full record

GuidelineJournal of pediatric gastroenterology and nutrition2025

ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain-not otherwise specified in children aged 4-18 years.

Jip Groen, Morris Gordon, Ashish Chogle, Marc Benninga, Rachel Borlack, Osvaldo Borrelli, Anil Darbari, Jernej Dolinsek, Julie Khlevner, Carlo Di Lorenzo and 8 more

Registry-linked trialAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07216092 (The Role of Audio-recorded Gut-hypnotherapy on Sleep Disturbance, Sleep-related Impairment and Abdominal Pain in Pediatric Functional Abdominal Pain Disorders), which is not on this map. Cited by 19 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07216092 nacompletednot on this map

The Role of Audio-recorded Gut-hypnotherapy on Sleep Disturbance, Sleep-related Impairment and Abdominal Pain in Pediatric Functional Abdominal Pain Disorders

TypeinterventionalSponsorChildren's Hospital at MontefioreRan2023 to 2024Enrolled46ConditionsIrritable Bowel Syndrome, Disorders of Gut-brain InteractionArmsGut-directed Hypnotherapy
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Efficacy and Safety ofNutrients · 2026
    Pooled it
  2. Guideline
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Guideline
  7. Effectiveness of hypnotherapy for paediatric abdominal pain in primary care: a randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jip GroenAmsterdam UMC, Pediatric Gastroenterology, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0007-7465-7549
Morris GordonSchool of Medicine, University of Central Lancashire, Preston, UK.
Ashish ChogleChildren's Hospital of Orange County, Orange, California, USA.
Marc BenningaAmsterdam UMC, Pediatric Gastroenterology, Amsterdam, The Netherlands.
Rachel BorlackThe Children's Hospital at Montefiore, Albert Einstein College of Medicine, New York, New York, USA.
Osvaldo BorrelliGreat Ormond Street Hospital, London, UK.
Anil DarbariChildren's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Jernej DolinsekUniversity Medical Centre Maribor, Maribor, Slovenia.
Julie KhlevnerColumbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Carlo Di LorenzoNationwide Children's Hospital, Columbus, Ohio, USA.
Hannibal PersonSeattle Children's Hospital, Seattle, Washington, USA.
Rinarani SanghaviChildren's Medical Center, Dallas, Texas, USA.
Julie SnyderBoston Children's Hospital, Boston, Massachusetts, USA.
Nikhil ThaparQueensland Children's Hospital, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Arine VliegerSt. Antonius Hospital, Nieuwegein, The Netherlands.
Vasiliki SinopoulouUniversity of Central Lancashire, Preston, UK.
Merit TabbersAmsterdam UMC, Pediatric Gastroenterology, Amsterdam, The Netherlands.
Miguel SapsUniversity of Miami, Miami, Florida, USA.

Funding

ESPGHANNASPGHAN
6 · The paper itself

Abstract

objectivesAbdominal pain related disorders of gut-brain interaction (AP-DGBIs) such as irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP) are common conditions in children, significantly impacting quality of life. This treatment guideline for IBS and FAP in children of 4-18 years is a collaborative effort of the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN and NASPGHAN). We aim to comprehensively review the current evidence on treatment options and offer evidence-based recommendations with utility across all treatment settings worldwide, as well as to provide methodological directions for future research.

methodsThe guideline development followed the "Grading of Recommendations Assessment, Development and Evaluation" (GRADE) approach, which is in accordance with the GRADE handbook and supported by the World Health Organization. The Guideline Development Group (GDG) comprised clinical experts, representing ESPGHAN, NASPGHAN, and Cochrane. Individual members have put forward a final consensus list of treatment options, which were then translated into "patient, intervention, comparison, outcome" (PICO) format options. Prospective agreement on decision thresholds for efficacy and safety outcomes was reached through a Delphi process among the GDG to support GRADEing of the literature. Consensus voting was used to finalize recommendations, and a treatment algorithm was developed.

resultsSystematic literature searches for this output identified 86 original randomized controlled trials assessing treatment of IBS and FAP. Consensus was reached for 25 GRADEd recommendations. Ten best practice statements were formulated, and guidance for future research methodology was proposed.

conclusionThis guideline represents the first collaborative output of ESPGHAN and NASPGHAN on treatment options for AP-DGBIs. Systematic review of the evidence has exposed major evidence gaps for the treatment of these disorders and incentivizes large pediatric trials, particularly on treatment options for which, to date, no evidence exists.

Indexed as

Abdominal PainIrritable Bowel SyndromeAdolescentChildChild, PreschoolGastroenterologyHumansSystematic Reviews as Topicdisorders of gut brain interactionfunctional abdominal paingut‐brain psychotherapiesirritable bowel syndromepediatric

Identifiers

PMID40444524
PMCPMC12314588

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.