Evidence map›Paper›PMID 40445192›Full record

ArticleeLife2025

A suite of selective pressures supports the maintenance of alleles of a

Sarah R Mullinax, Andrea M Darby, Anjali Gupta, Patrick Chan, Brittny R Smith, Robert L Unckless

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The Gut Microbiota ofMicroorganisms · 2025
    Review
  5. Is it time to assignApplied and environmental microbiology · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sarah R MullinaxDepartment of Molecular Biosciences, University of Kansas, Lawrence, United States.
Andrea M DarbyDepartment of Entomology, Cornell University, Ithaca, United States.
Anjali GuptaDepartment of Ecology and Evolutionary Biology, University of Kansas, Lawrence, United States.ORCID https://orcid.org/0000-0002-5717-543X
Patrick ChanDepartment of Molecular Biosciences, University of Kansas, Lawrence, United States.
Brittny R SmithDepartment of Molecular Biosciences, University of Kansas, Lawrence, United States.
Robert L UncklessDepartment of Molecular Biosciences, University of Kansas, Lawrence, United States.ORCID https://orcid.org/0000-0001-8586-7137

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
The causes of balancing selection on immunity genes: from populations to molecular interactions.R01AI139154 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI UNCKLESS, ROBERT L · 2018 to 2022
$1.9M
National Science Foundation 2330095NIAID NIH HHS R01 AI139154NIGMS NIH HHS P20 GM103638NIH HHS AI139154NIH HHS CMADP COBRE P20-GM103638
6 · The paper itself

Abstract

The innate immune system provides hosts with a crucial first line of defense against pathogens. While immune genes are often among the fastest evolving genes in the genome, in

Indexed as

AllelesAntimicrobial PeptidesDrosophilaDrosophila melanogasterDrosophila ProteinsSelection, GeneticAnimalsFemaleGastrointestinal MicrobiomeMaleProvidenciaAntimicrobial PeptidesDrosophila Proteinsantimicrobial peptideDiptericinD. melanogasterevolutionary biologyinfectious diseaseinnate immunitymicrobiologyProvidencia

Identifiers

PMID40445192
PMCPMC12124834

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.