ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Oleuropein modulates anti-inflammatory activity of celecoxib and ketoprofen through cyclooxygenase pathway: in vivo, in silico and pharmacokinetics approaches.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- A comprehensive review ofRSC advances · 2026Review
- Preparation of Quercetin-Loaded Lipid Nanoparticle-Embedded Hydrogels and Stability Studies.Molecules (Basel, Switzerland) · 2026Article
- Oleuropein derived from olive leaves inhibits the activity ofRSC advances · 2026Article
- Combining anxiolytic activity of thymol and trans-ferulic acid: a potential GABAergic intervention.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Linalool exerts antiemetic effects via dopaminergic and serotonergic pathways: Evidence from chick model and molecular docking.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oleuropein (OLP), a bioactive compound mainly found in olive leaves, is recognized for its wide range of biological effects, such as antioxidant, anti-inflammatory, and antimicrobial activities. This study aimed to assess the anti-inflammatory effects of OLP in an in vivo model and explore its molecular interactions through in silico docking studies. We investigated the individual and combined effects of OLP (10 and 20 mg/kg) alongside standard anti-inflammatory drugs, celecoxib (CXB) and ketoprofen (KPN), at 42 mg/kg (p.o.) in a formalin-induced inflammatory chick model. In addition, an in silico analysis was conducted to examine how OLP and the standard drugs interact with cyclooxygenase (COX)-1 and COX-2 enzymes. The results indicated that OLP exhibited a dose-dependent anti-inflammatory effect in chicks, with OLP-20 mg/kg significantly reducing paw-licking frequency and paw edema diameters. Furthermore, the combination of OLP-20 mg/kg with CXB-42 mg/kg and KPN-42 mg/kg showed enhanced anti-inflammatory efficacy. In the molecular docking analysis, OLP demonstrated comparable binding interactions with both COX-1 (‒7.6 kcal/mol) and COX-2 (‒7.7 kcal/mol) enzymes, similar to the standard drugs. Pharmacokinetic (PK) analysis revealed that OLP has favorable properties and a safe toxicity profile, with an LD
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.