Evidence map›Paper›PMID 40445460›Full record

ArticleNeurochemical research2025

Protective Effect of FABP5 Against 6-OHDA Induced Parkinson's Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway.

Yinying Ni, Muhammad Abid Hayat, Yu Si, Tao Guo, Jingwen Zhang, Yancheng Hong, Yudie Cao, Sijia He, Zijuan Weng, Fengmei Li and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yinying NiJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Muhammad Abid HayatJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Yu SiJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Tao GuoJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Jingwen ZhangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Yancheng HongJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Yudie CaoJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Sijia HeJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Zijuan WengJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Fengmei LiJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
Bo ChenInstitute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, 212002, China.
Hao ZuoZhenjiang Blood Center, Zhenjiang, Jiangsu, 212013, China.
Xin SunZhenjiang Blood Center, Zhenjiang, Jiangsu, 212013, China.
Jiabo HuJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China. hu@ujs.edu.cn.ORCID https://orcid.org/0000-0003-1974-984X

Funding

Science andTechnology Cooperation Foundation of Health BioMed Grant No. 20200605Zhenjiang Science and Technology Plan (Social Development) Project SH2024015
6 · The paper itself

Abstract

Mitochondrial dysfunction of neurons is an important feature of Parkinson's disease (PD). Fatty acid binding protein 5 (FABP5) is a protein that regulates mitochondrial function and protects cell from neuronal injury. However, the potential of FABP5 administration to restore mitochondria has not been fully explored. In this study, PC12 cells and rats were induced by 6-hydroxydopamine (6-OHDA) to establish PD models. Our results showed that FABP5 promoted cell proliferation and protected against mitochondrial damage, and reduced apoptosis in vitro and vivo. Moreover, FABP5 treatment alleviates motor and non-motor symptom injury in vivo. It also effectively modulated the PPARγ/SIRT1/PGC-1α signaling pathway, thereby mitigating 6-OHDA-induced neurotoxicity. These results suggest that FABP5 exerts mitochondrial protection, inhibits apoptosis, restores damaged dopaminergic neurons, and slows down PD.

Indexed as

Fatty Acid-Binding ProteinsNeuroprotective AgentsOxidopaminePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaSignal TransductionSirtuin 1AnimalsApoptosisDopaminergic NeuronsMaleMitochondriaParkinson DiseasePC12 CellsRatsRats, Sprague-DawleyFatty Acid-Binding ProteinsNeuroprotective AgentsOxidopaminePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaPpargc1a protein, ratSirt1 protein, ratSirtuin 1ApoptosisFatty acid binding protein 5mitochondrial dysfunctionParkinson's diseasePPARγ

Identifiers

PMID40445460

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.