Evidence mapPaperPMID 40445470Full record

ReviewDiscover oncology2025

Modern therapeutic approaches for hepatic tumors: progress, limitations, and future directions.

Shayan Sadrinasab, Sadaf Saket, Nadia Pourmohammadi, Fatemeh Khosravi, Masoud Saadat Fakhr

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shayan SadrinasabSchool of Medicine, Shahid Beheshti School of Medicine, Tehran, Iran.
Sadaf SaketShahid Beheshti University of Medical Science and Health Services, Taleghani Hospital, Tehran, Iran.
Nadia PourmohammadiFaculty of Medicine, Shahroud University of Medical Scienses, Shahroud, Iran.
Fatemeh KhosraviFaculty of Medicine, Tehran Medical Sciences School Branch, Islamic Azad University, Tehran, Iran.
Masoud Saadat FakhrFaculty of Medicine, Tehran Medical Sciences School Branch, Islamic Azad University, Tehran, Iran. masoud.saadatfakhr@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic tumors, such as hepatocellular carcinoma (HCC) and metastatic liver malignancies, represent a substantial worldwide health concern due to elevated mortality rates and unfavorable prognoses. Notwithstanding progress in surgical, locoregional, and systemic therapy, significant obstacles like as late-stage diagnosis, treatment resistance, and discrepancies in healthcare access still hinder patient outcomes. This study thoroughly analyzes recent breakthroughs in hepatic tumor treatment, including surgical improvements, immunotherapy, targeted medicines, and nanotechnology-based drug delivery systems. The discourse emphasizes minimally invasive methods including laparoscopic and robotic-assisted hepatectomies, the function of immune checkpoint inhibitors, and the promise of nanoparticle-based therapeutics to improve drug administration while reducing systemic toxicity. This study aims to critically assess current hepatic tumor treatments, examining their effectiveness, constraints, and prospective developments. Critical concerns, such as drug resistance, post-treatment recurrence, and the accessibility of innovative medicines in resource-constrained environments, are addressed. The review underscores the significance of personalized medicine, biomarker-guided treatment approaches, and interdisciplinary teamwork in enhancing therapeutic results. Future research seeks to enhance patient survival and quality of life through the integration of developing technology and the refinement of present treatment approaches.

Indexed as

Hepatic tumorsHepatocellular carcinoma (HCC)ImmunotherapyLiver cancer treatmentNanotechnologySurgical innovations

Identifiers

PMID40445470
PMCPMC12125458

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.