ArticlePharmacological reports : PR2025
Biomarkers associated with antidepressant response and illness severity in major depressive disorder: a pilot study.
Article in Pharmacological reports : PR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Role of Age at Onset on the Clinical Course and Biochemical Parameters of Anorexia Nervosa.Journal of personalized medicine · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor Depressive Disorder (MDD) is a prevalent condition characterized by alterations in different biological systems including inflammatory and antioxidant pathways. Antidepressants seem to rebalance biological abnormalities. In this short communication, we report differences in a set of biomarkers between drug-free patients and those who benefited from response to antidepressant monotherapy.
methodsA sample of patients affected by MDD (N = 38) was recruited at the inpatient and outpatient clinic of Policlinico Hospital in Milan: 26 responders and 12 drug-free subjects. The two groups of patients were compared by χ2 tests and analyses of variance, respectively, for qualitative and continuous variables. Correlation analyses were performed to evaluate the relationship between rating scale scores (severity of MDD) and biological parameters.
resultsDrug-free patients (compared to the counterpart) had a higher number of previous suicide attempts (p < 0.01), lower levels of plasmatic proteins (p < 0.01), albumin (p = 0.02), and total cholesterol (p = 0.02), but higher plasma levels of dehydroepiandrosterone sulfate (DHEAs) (p = 0.02), adrenocorticotropic hormone (ACTH) (p < 0.01) and angiotensin converting enzyme (ACE) (p = 0.02).
conclusionsThe results of the present study suggest that the severity of MDD is associated with more prominent biological changes, and antidepressants might mitigate these abnormalities. Future studies with larger samples are needed to confirm these preliminary findings.
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