ReviewAmerican journal of physiology. Cell physiology2025
The multifaced role of the macrophage migration inhibitory factor family in organ fibrosis.
Review in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrating Single-Cell Transcriptomics and Mendelian Randomization to Identify RAC1 as a Causal Metabolic Driver of Pericyte Dysfunction in Systemic Sclerosis.Mediators of inflammation · 2026Article
- [Causal relationship between circulating cytokines and keloids: A Mendelian randomized study].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The macrophage migration inhibitory factor (MIF) family consists of the structurally homologous proteins MIF, D-dopachrome tautomerase (D-DT), and D-DT like (D-DTL). Although MIF is the most well-described member, much less is known about D-DT, and very little about D-DTL. Here, we provide an overview of the structure, similarities, and biological functions of these proteins. MIF and D-DT can have both protective and aggravating effects on various diseases depending on the disease type, involved organ, cell type, and disease stage. Given that the pathological consequence of many chronic diseases is fibrosis, we here discuss the role of these proteins in organ fibrosis, particularly of the kidney, liver, heart, lung, and skin. We discuss the various roles of these proteins, suggesting that MIF might have pro- and antifibrotic roles in different organs. To date, D-DT has been shown to have only antifibrotic roles. We tackle potential translational considerations and propose future research avenues to better understand the involvement of MIF family in organ fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.