Evidence map›Paper›PMID 40445765›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Genomic analyses identify 15 risk loci and reveal

Shawna R Cook, Sanne Hugen, Jessica J Hayward, Thomas R Famula, Janelle M Belanger, Elizabeth McNiel, Hille Fieten, Anita M Oberbauer, Peter A J Leegwater, Elaine A Ostrander and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Genomic analyses identify 15 risk loci and revealProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Shawna R CookBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-7967-9607
Sanne HugenExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.
Jessica J HaywardDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-6213-5013
Thomas R FamulaDepartment of Animal Science, University of California, Davis, CA 95616.ORCID 0000-0002-3139-9849
Janelle M BelangerDepartment of Animal Science, University of California, Davis, CA 95616.
Elizabeth McNielCummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536.
Hille FietenExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.ORCID 0000-0002-0562-6964
Anita M OberbauerDepartment of Animal Science, University of California, Davis, CA 95616.ORCID 0000-0002-3945-2851
Peter A J LeegwaterExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.
Elaine A OstranderCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-6075-9738
Paul J J MandigersExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.
Jacquelyn M EvansBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-1272-0059

Funding

HHS | NIH | National Human Genome Research Institute (NHGRI) Intramural Program
6 · The paper itself

Abstract

Gastric cancer ranks as the fifth most common human cancer worldwide and has a poor survival rate and limited treatment options. Despite the high prevalence and mortality rate, the genetic etiology is largely unknown. In dogs, a clinically and histologically similar disease disproportionately affects two breeds, the Belgian Tervuren and Belgian Sheepdog, which develop the intestinal and diffuse tumor subtypes observed in humans. We performed a Bayesian genome-wide association study and selection analyses in this naturally occurring canine model to elucidate underlying genetic risk factors for gastric cancer and identified 15 associated loci. Variant filtering revealed germline putative regulatory variants for the

Indexed as

Dog DiseasesRNA-Binding ProteinsSOXB1 Transcription FactorsStomach NeoplasmsAnimalsDisease Models, AnimalDogsGenetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideRisk FactorsRNA-Binding ProteinsSOXB1 Transcription FactorsadenocarcinomaBayesian GWASBelgian shepherddogPDZRN3

Identifiers

PMID40445765
PMCPMC12146739

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.