Evidence map›Paper›PMID 40445776›Full record

Trial reportDiabetes technology & therapeutics2025

Fully Closed-Loop Improves Glycemic Control Compared with Pump with CGM in Adolescents with Type 1 Diabetes and HbA1c Above Target: A Two-Center, Randomized Crossover Study.

Nithya Kadiyala, Rama Lakshman, Janet Allen, Julia Ware, Charlotte K Boughton, Malgorzata E Wilinska, Ajay Thankamony, Sara Hartnell, Hood Thabit, Ruben H Willemsen and 2 more

Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes technology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Revolutionizing Diabetes Care: From Tech to Therapeutics.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nithya KadiyalaWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-4285-4656
Rama LakshmanWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Janet AllenWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Julia WareWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-4497-0979
Charlotte K BoughtonWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-3272-9544
Malgorzata E WilinskaWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Ajay ThankamonyDepartment of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
Sara HartnellWolfson Diabetes and Endocrine Clinic, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Hood ThabitDiabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Ruben H WillemsenDepartment of Paediatric Diabetes and Endocrinology, The Royal London Children's Hospital, Barts Health NHS Trust, London, United Kingdom.
Pratik ShahDepartment of Paediatric Diabetes and Endocrinology, The Royal London Children's Hospital, Barts Health NHS Trust, London, United Kingdom.
Roman HovorkaWellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.ORCID //orcid.org/0000-0003-2901-461X

Funding

Department of Health NIHR203312
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1Glycated HemoglobinGlycemic ControlHypoglycemic AgentsInsulin AspartInsulin Infusion SystemsAdolescentBlood Glucose Self-MonitoringCross-Over StudiesFemaleHumansInsulinMaleYoung AdultBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsInsulinInsulin Aspartadolescentsartificial pancreasautomated insulin deliveryfully-closed looptype 1 diabetes

Identifiers

PMID40445776
PMCPMC7618673

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.