Evidence map›Paper›PMID 40445960›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Intersecting transcriptomic landscapes of hypertension and kidney function in African American women.

Malak Abbas, Pamela Martin, Merry L Lindsey, Eric S Bennett, Thomas L Brown, Chike Nzerue, Clintoria R Williams, Amadou Gaye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Shared Genetics of Hypertension and Preeclampsia Converges on Immune Regulation.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Malak AbbasNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-5484-5875
Pamela MartinDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, United States.
Merry L LindseyDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, United States.ORCID 0000-0002-4090-0391
Eric S BennettDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Cardio-Renal Institute, Wright State University, Dayton, Tennessee, United States.ORCID 0000-0002-1605-7250
Thomas L BrownDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Cardio-Renal Institute, Wright State University, Dayton, Tennessee, United States.
Chike NzerueInternal Medicine, Meharry Medical College, Nashville, Tennessee, United States.
Clintoria R WilliamsDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Cardio-Renal Institute, Wright State University, Dayton, Tennessee, United States.ORCID 0000-0001-7026-7737
Amadou GayeDepartment of Integrative Genomics and Epidemiology, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, United States.ORCID 0000-0002-1180-2792

Funding

Short Course In Transferable Skills Training (SHIFT) ProgramR25GM151274 · MEHARRY MEDICAL COLLEGE · 2025 to 2025
$486k
STrengthening Research OpportuNities for Growth at Meharry Medical College (Meharry-STRONG)UC2MD019626 · MEHARRY MEDICAL COLLEGE · 2025 to 2025
$364k
Chan Zuckerberg Initiative (CZI)CSRD VA I01 CX002780Intramural NIH HHS Z99 DK999999NIGMS NIH HHS R25 GM151274NIMHD NIH HHS UC2 MD019626U.S. Department of Veterans Affairs (VA)
6 · The paper itself

Abstract

Hypertension is a risk factor for chronic kidney disease (CKD) and disproportionately affects African American women, contributing to disparities in kidney health. The biological mechanisms connecting hypertension to reduced kidney function remain poorly understood. This study leverages transcriptomic analyses to uncover shared molecular signatures associated with hypertension and kidney function, focusing on female-specific profiles. The study analyzed whole blood mRNA sequencing data from 344 African American women, divided into discovery (

Indexed as

Black or African AmericanGlomerular Filtration RateHypertensionKidneyRenal Insufficiency, ChronicTranscriptomeAdultAgedFemaleGene Expression ProfilingHumansMaleMiddle AgedRisk FactorsSex FactorsAfrican Americanhypertensionkidney functiontranscriptomewomen

Identifiers

PMID40445960
PMCPMC12316382

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.