ArticleAnalytical chemistry2025
One-Drop Serum Screening Test to Monitor Tissue Iron Accumulation.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are critical for preventing irreversible damage and improving patient survival rates. Diagnosing tissue iron deposits relieves invasive biopsies with atomic absorption spectrometry (reserved for specific cases) or noninvasive but costly and time-consuming imaging techniques like computerized tomography and magnetic resonance, which provide limited analytical data and are unsuitable for routine screening. As an alternative, Fourier transform infrared spectroscopy combined with machine learning has emerged as a promising approach for supporting medical decision-making. In this study, we developed a minimally invasive method to identify IO and quantify iron levels in blood and tissues (heart, liver, spleen, and kidney) without biopsies. PLS-DA classification models and PLS regression models were constructed based on samples categorized into a control group (
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