Evidence map›Paper›PMID 40447068›Full record

ArticleEuropean journal of pharmacology2025

NOSH-aspirin (NBS-1120) attenuates motor defects and dopaminergic neuron degeneration in a rat model of Parkinson's disease.

Bita Firouzan, Rasoul Ghasemi, Michael T Tetteh, John B Matson, Khosrow Kashfi

Abstract read
In one paragraph

Article in European journal of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The role of gasotransmitters in Parkinson's disease: Interplay of nitric oxide, carbon monoxide, and hydrogen sulfide.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  4. Gasotransmitter signaling in the brain: New frontiers for therapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bita FirouzanNeuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rasoul GhasemiDepartment of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: rghasemi60@sbmu.ac.ir.
Michael T TettehDepartment of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA, 24061, USA.
John B MatsonDepartment of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA, 24061, USA.
Khosrow KashfiDepartment of Molecular, Cellular & Biomedical Sciences, City University of New York School of Medicine, New York, NY, 10031, USA; Graduate Program in Biology, City University of New York Graduate Center, New York, 10091, USA. Electronic address: kashfi@med.cuny.edu.

Funding

Research Center in Minority Institutions (RCMI) at City CollegeU54MD017979 · NIMHD · CITY COLLEGE OF NEW YORK · PI M. Felice Marina GHILARDI · 2024 to 2026
$15.9M
Delivery of H2S: Supramolecular and Enzyme-Triggered Strategies for Controlled ReleaseR01GM123508 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MATSON, JOHN B · 2017 to 2021
$1.6M
NIGMS NIH HHS R01 GM123508NIMHD NIH HHS U54 MD017979
6 · The paper itself

Abstract

Parkinson's disease (PD) is a chronic, debilitating neurodegenerative disorder marked by the progressive and irreversible loss of dopaminergic (DA) neurons in the nigrostriatal pathway. Although the precise mechanisms underlying PD remain unclear, extensive research suggests that chronic neuroinflammation plays a significant role in its pathogenesis. Recently, growing evidence has pointed to NOSH-aspirin, an aspirin derivative that releases both nitric oxide (NO) and hydrogen sulfide (H

Indexed as

AspirinDopaminergic NeuronsMotor ActivityNerve DegenerationNeuroprotective AgentsParkinson DiseaseParkinsonian DisordersAnimalsBehavior, AnimalDisease Models, AnimalMaleOxidopamineRatsRats, WistarAspirinNeuroprotective AgentsOxidopamine6-HydroxydopamineDopaminergic neuronsNeuro-inflammationNOSH-AspirinParkinson's disease

Identifiers

PMID40447068
PMCPMC12229780

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.