Evidence mapPaperPMID 40447582Full record

ReviewNature communications2025

From precision interventions to precision health.

Nicholas J Schork, Laura H Goetz

Abstract readReview
In one paragraph

Review in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Lanthanide Nanotheranostics in Radiotherapy.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicholas J SchorkThe Translational Genomics Research Institute, a part of the City of Hope National Medical Center, Phoenix, AZ (NJS, LHG), USA. nschork@tgen.org.ORCID http://orcid.org/0000-0003-0920-5013
Laura H GoetzThe Translational Genomics Research Institute, a part of the City of Hope National Medical Center, Phoenix, AZ (NJS, LHG), USA.ORCID http://orcid.org/0000-0003-0061-4769

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
Regulatory and Human Study Operations (RHSO) Core CU19AG065169 · NIA · UNIVERSITY OF ARIZONA · PI SCHORK, NICHOLAS JOSEPH · 2021 to 2025
$59.8M
Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategiesUH3AG064704 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2022 to 2025
$14.7M
Exceptional Longevity Data Management and Coordinating CenterU24AG078753 · NIA · SAGE BIONETWORKS · PI Christine M. Fabre Suver, Solveig Sieberts · 2022 to 2026
$10.3M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
Novel Biomarkers and Genetics of Diabetic RetinopathyR01EY028606 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DAS, ARUP · 2018 to 2022
$2.8M
Integrative Omics to enhance therapeutics development for healthy agingUH2AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI EVANS, DANIEL SPENCER, MILLER, RICHARD A · 2019 to 2020
$1.4M
BLRD VA I01 BX005348Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 5R01EY028606-04Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) U19 AG065169-01A1Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) U24AG078753Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) UH3-AG064706NEI NIH HHS R01 EY028606NIA NIH HHS U19 AG023122NIA NIH HHS U19 AG065169NIA NIH HHS U24 AG078753NIA NIH HHS UH2 AG064706NIA NIH HHS UH3 AG064704NIA NIH HHS UH3 AG064706
6 · The paper itself

Abstract

Precision medicines, or those medicines that are tailored to individual genetic, molecular, physiologic, behavioral, and/or exposure profiles, are being developed at a rapid pace. However, just how precise these interventions are in terms of their mechanisms of action (MOAs), clinical effects, and utility in different individuals, are hard anticipate with current preclinical research and clinical trials strategies. To understand how various genes, processes, organs, clinical phenotypes, etc. may be impacted by an intervention, as well as how many people might benefit from it, appropriate data on living human beings needs to be collected as part of built-for-purpose clinical trials.

Indexed as

Precision MedicineAnimalsClinical Trials as TopicHumans

Identifiers

PMID40447582
PMCPMC12125267

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.